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TargetMol | Compound Library

Tyrosine Kinase Inhibitor Library

Catalog No. L2200

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis. The Tyrosine Kinase Inhibitors Library by TargetMol, containing 1016 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2200

Tyrosine Kinase Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Library Customization | TargetMol Library Composition

EGFR
VEGFR
Apoptosis
Src
FLT
PDGFR
Autophagy
FGFR
c-Kit
c-Met/HGFR
Bcr-Abl
ALK
PKA
HER
Tyrosine Kinases
JAK
IGF-1R
CDK
FAK
c-RET
Trk receptor
TAM Receptor
c-Fms
Syk
Aurora Kinase
PKC
Raf
DYRK
Akt
BTK
TGF-beta/Smad
ERK
ROS Kinase
Ephrin Receptor
CSF-1R
Potassium Channel
Endogenous Metabolite
Discoidin Domain Receptor (DDR)
S6 Kinase
p38 MAPK
GSK-3
NF-κB
5-HT Receptor
PI3K
Antibacterial
Tie-2
Calcium Channel
ROCK
ROS
Serine/threonin kinase
PYK2
Chk
mTOR
Ferroptosis
JNK
Cytochromes P450
MAPK
Casein Kinase
MEK
TNF
Microtubule Associated
Antibiotic
Drug Metabolite
ACK1
COX
STAT
HDAC
Sodium Channel
Tyrosinase
MLK
HIV Protease
PROTACs
Histamine Receptor
Pim
RIP kinase
PDE
Reactive Oxygen Species
CaMK
DNA/RNA Synthesis
SARS-CoV
Influenza Virus
IκB/IKK
Beta Amyloid
SGK
AChR
Ligands for Target Protein for PROTAC
Antifungal
Mitophagy
Parasite
Hck
Caspase
Adrenergic Receptor
MAO
MNK
Antiviral
HSP
PDK
AMPK
Phospholipase
PLK
IRAK
HCV Protease
Dehydrogenase
Adenosine Receptor
Phosphatase
Virus Protease
PPAR
Topoisomerase
Myosin
IRE1
LDL
GRK
IL Receptor
MMP
GluR
Interleukin
Sigma receptor
p53
Melanin-concentrating Hormone Receptor (MCHR)
Carbonic Anhydrase
DHFR
ROR
DNA-PK
Histone Methyltransferase
Integrin
Estrogen/progestogen Receptor
YAP
Antioxidant
Na+/Ca2+ Exchanger
IFNAR
NADPH
GTPase
Estrogen Receptor/ERR
Wnt/beta-catenin
Rho
Serine Protease
Antifolate
Serotonin Transporter
Cell Cycle Arrest
Nucleoside Antimetabolite/Analog
LIM Kinase
Glucokinase
NAMPT
E1/E2/E3 Enzyme
Haspin Kinase
NMDAR
Mitochondrial Metabolism
Monoamine Transporter
Hedgehog/Smoothened
DNA Alkylation
FAAH
HSV
CCR
PAD
Epigenetic Reader Domain
Lipoxygenase
Norepinephrine
DUB
BCRP
P-gp
TLR
LRRK2
Sirtuin
Bcl-2 Family
Histone Acetyltransferase
transporter
PAI-1
MELK
RSV
Hippo pathway
Reverse Transcriptase
Protease
GPR
CRISPR/Cas9
HIF
Gap Junction Protein
DAPK
p97
HIF/HIF Prolyl-Hydroxylase
IGF-2R