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Search Results for " microglial "

Targets

24

Compounds

14

Natural Products

30

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T7100 PLX5622 PLX-5622 c-Fms , CSF-1R
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
T15199 Edicotinib JNJ-527,JNJ-40346527 c-Fms , FLT , CSF-1R , c-Kit
Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote...
T8811 Tuftsin 3TFA Endogenous Metabolite
Tuftsin 3TFA is a tetrapeptide. It is a macrophage/microglial activator.
T60932 MAO-B-IN-8 MAO
MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neuroinflammatory mediators. This compound is specifically des...
T14384 AZD8797 KAN-0440567,KAND567 CXCR
AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventi...
TP1786L Amyloid β-Protein 10-20 acetate Amyloid β-Protein 10-20 acetate(152286-31-2 free base) Beta Amyloid
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α...
T10809 CHPG Others
CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway.
T70367 SNU-BP
SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polari...
T79371 HDAC-IN-62 Autophagy
HDAC-IN-62 (Compound 5), an HDAC inhibitor, exhibits IC50 values of 0.78, 1.0, and 1.2 μM for HDAC6, HDAC8, and HDAC11, respectively. This compound suppresses microglial activation via autophagy induction and reduces nit...
T37815 PM226 PM 226
Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microg...
TP1846 Tuftsin diacetate
Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectr...
T37726 MMP-9 Inhibitor I
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TAC...
T81685 NEP(1-40) TFA
NEP(1-40) TFA is a peptide antagonist of the Nogo-66 receptor (NgR), which mitigates the shift in microglial morphology distributions due to injury by attenuating myelin-derived inhibition [1].
T80682 γ-Fibrinogen 377-395 TFA
γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Addition...
T80683 γ-Fibrinogen 377-395
γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimen...
T62612 CD33 splicing modulator 1
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid cell surface receptor known to regulate microglial cell activity. CD33 splicing modulator 1 has potential for the study of n...
TP1786 β-Amyloid (10-20) Amyloid β-Protein 10-20
Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains ...
T12505 PLX5622 hemifumarate c-Fms
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate allows for extended and specific microglial elimination, prece...
T79484 Nrf2 activator-8
Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties in BV-2 microglial cells. Furthermore, this compound notably...
T35864 T-5342126
T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isola...
T83798 8-bromo NAD+ sodium 8-bromo Nicotinamide adenine dinucleotide,N(8-bromo-A)D+
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in in...
T83777 LAU-0901
LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO)-induced ...
T75339 Methylene blue hydrate
Methylene Blue (Basic Blue 9) hydrate functions as an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). This compound, known for its vasopressor activity, is widely utilized as a dy...
T83895 NCI 126224 NSC 126224
NCI 126224, a toll-like receptor 4 (TLR4) antagonist, demonstrates selective inhibition of nitric oxide (NO) production in RAW 264.7 macrophages, triggered by the TLR4 agonist LPS (IC50 = 0.31 µM), as opposed to minimal ...
Cat No. Product Name Synonyms Targets
TN6714 Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095 Apoptosis
Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) ...
T3896 Shanzhiside methyl ester Glucagon Receptor
Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling.
TWS1977 Kamebakaurin Kamebakaurine NF-κB
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression...
T4S1962 Beta-Asarone Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin NF-κB , JNK
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be...
T3824 Jaceosidin Apoptosis , BCL , COX , UGT
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...
T82211 Herpotrichone B
Herpotrichone B exhibits significant anti-neuroinflammatory activity by inhibiting lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells, demonstrating a half maximal inhibitory concentration (IC50) of 0...
TN4182 Hannokinol Others
(+)-Hannokinol and MESO-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM.
T83056 Anti-inflammatory agent 5
Anti-inflammatory agent 5 effectively inhibits nitric oxide (NO) production in lipopolysaccharide-induced BV-2 microglial cells.
T82212 Herpotrichone A
Herpotrichone A exhibits strong anti-neuroinflammatory effects in BV-2 microglial cells induced by lipopolysaccharide (LPS), achieving a half maximal inhibitory concentration (IC50) of 0.41 μM.
TN5248 Voleneol NOS , COX , Prostaglandin Receptor
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxid...
T83553 (4S)-10-Nor-calamenen-10-one
(4S)-10-Nor-calamenen-10-one (Compound 15), an eudesmane sesquiterpene sourced from Alpinia oxyphylla [1], amplifies LPS-induced nitric oxide (NO) production in microglial cells.
TN5011 Shizukaol B ERK , IL Receptor , p38 MAPK , TNF , NOS , NF-κB , COX , HIV Protease , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production...
TN2641 15-Methoxypinusolidic acid ERK , IL Receptor , p38 MAPK , Calcium Channel , NOS , NF-κB , COX , JNK , NMDAR , PPAR
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation thro...
T36417 Nargenicin Antibiotic 47444
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03203 CD40 Protein, Rat, Recombinant (His) Rat HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-01181 CD40 Protein, Human, Recombinant (His) Human HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-05957 CD40 Protein, Mouse, Recombinant (His) Mouse HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-01148 TREM-2 Protein, Human, Recombinant (His) Human HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-00432 TREM-2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01703 TREM-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPK-00734 CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li...
TMPK-00018 CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) Human E. coli
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li...
TMPK-00735 CXCL13/BCA-1 Protein, Mouse, Recombinant (His) Mouse HEK293
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li...
TMPK-00017 CXCL13/BCA-1 Protein, Human, Recombinant (hFc) Human HEK293
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li...
TMPK-00188 JAM-A Protein, Mouse, Recombinant (His) Mouse HEK293
junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor mi...
TMPH-02231 NRROS Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi...
TMPH-02230 NRROS Protein, Human, Recombinant (His & Myc) Human Baculovirus
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi...
TMPH-02803 NRROS Protein, Mouse, Recombinant (His) Mouse E. coli
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi...
TMPY-03907 CD40 Protein, Canine, Recombinant (hFc) Canine HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-03944 CD40 Protein, Canine, Recombinant Canine HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-04089 CD40 Protein, Canine, Recombinant (His) Canine HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-03212 CD40 Protein, Rhesus, Recombinant (His) Rhesus HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-06024 CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-05614 CD40 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-05425 CD40 Protein, Mouse, Recombinant (hFc) Mouse HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-05599 CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-04994 CD40 Protein, Mouse, Recombinant (rFc) Mouse HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-00482 CD40 Protein, Human, Recombinant (hFc) Human HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-05359 CD40 Protein, Human, Recombinant (mFc) Human HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-03083 CD40 Protein, Rat, Recombinant (hFc) Rat HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-03211 CD40 Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory...
TMPY-06598 TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-06566 TREM-2 Protein, Human, Recombinant (hFc) Human HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPH-01364 Galectin-9/LGALS9 Protein, Human, Recombinant (GST & His) Human E. coli
Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macropha...
CD40 Protein, Rat, Recombinant (His)
TMPY-03203
Species: Rat
Expression System: HEK293
CD40 Protein, Human, Recombinant (His)
TMPY-01181
Species: Human
Expression System: HEK293
CD40 Protein, Mouse, Recombinant (His)
TMPY-05957
Species: Mouse
Expression System: HEK293
TREM-2 Protein, Human, Recombinant (His)
TMPY-01148
Species: Human
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (hFc)
TMPY-00432
Species: Mouse
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (His)
TMPY-01703
Species: Mouse
Expression System: HEK293
CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc)
TMPK-00734
Species: Mouse
Expression System: HEK293
CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo)
TMPK-00018
Species: Human
Expression System: E. coli
CXCL13/BCA-1 Protein, Mouse, Recombinant (His)
TMPK-00735
Species: Mouse
Expression System: HEK293
CXCL13/BCA-1 Protein, Human, Recombinant (hFc)
TMPK-00017
Species: Human
Expression System: HEK293
JAM-A Protein, Mouse, Recombinant (His)
TMPK-00188
Species: Mouse
Expression System: HEK293
NRROS Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-02231
Species: Human
Expression System: E. coli
NRROS Protein, Human, Recombinant (His & Myc)
TMPH-02230
Species: Human
Expression System: Baculovirus
NRROS Protein, Mouse, Recombinant (His)
TMPH-02803
Species: Mouse
Expression System: E. coli
CD40 Protein, Canine, Recombinant (hFc)
TMPY-03907
Species: Canine
Expression System: HEK293
CD40 Protein, Canine, Recombinant
TMPY-03944
Species: Canine
Expression System: HEK293
CD40 Protein, Canine, Recombinant (His)
TMPY-04089
Species: Canine
Expression System: HEK293
CD40 Protein, Rhesus, Recombinant (His)
TMPY-03212
Species: Rhesus
Expression System: HEK293
CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPY-06024
Species: Mouse
Expression System: HEK293
CD40 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-05614
Species: Human
Expression System: HEK293
CD40 Protein, Mouse, Recombinant (hFc)
TMPY-05425
Species: Mouse
Expression System: HEK293
CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPY-05599
Species: Human
Expression System: HEK293
CD40 Protein, Mouse, Recombinant (rFc)
TMPY-04994
Species: Mouse
Expression System: HEK293
CD40 Protein, Human, Recombinant (hFc)
TMPY-00482
Species: Human
Expression System: HEK293
CD40 Protein, Human, Recombinant (mFc)
TMPY-05359
Species: Human
Expression System: HEK293
CD40 Protein, Rat, Recombinant (hFc)
TMPY-03083
Species: Rat
Expression System: HEK293
CD40 Protein, Rhesus, Recombinant (hFc)
TMPY-03211
Species: Rhesus
Expression System: HEK293
TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06598
Species: Human
Expression System: HEK293
TREM-2 Protein, Human, Recombinant (hFc)
TMPY-06566
Species: Human
Expression System: HEK293
Galectin-9/LGALS9 Protein, Human, Recombinant (GST & His)
TMPH-01364
Species: Human
Expression System: E. coli
Cat No. Product Name
L9840 Anti-Alzheimer's Disease Compound Library

1040 compounds
A unique collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.
TargetMol