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Poloxamer 188
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Catalog No. T40802Cas No. 691397-13-4
Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice.
Poloxamer 188
😃Good
Catalog No. T40802Cas No. 691397-13-4
Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | Inquiry | Backorder | |
| 100 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice. |
| In vitro | Poloxamer 188 exhibited a protective effect on mouse brain microvascular endothelial cells (MBEC) after treatment in the concentration range of 10-1000 μM for 5 hours. In addition, Docetaxel-loaded PLGA/Poloxamer 188 nanoparticles significantly increased drug uptake levels and cytotoxicity in Docetaxel-resistant MCF-7 TAX30 human breast cancer cells compared to Docetaxel-loaded PLGA nanoparticles. [1][2] |
| In vivo | Poloxamer 188 administered intravenously at a dose of 150 mg/kg over 240 minutes significantly reduced muscle edema and lipid peroxidation induced by ischemia-reperfusion. [3] |
| Cas No. | 691397-13-4 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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