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HAMI 3379 (HAMI3379) is a selective cysteinyl leukotriene receptor 2 (CysLT2) antagonist that dose- and time-dependently attenuates brain damage and inhibits microglial cell inflammation following focal cerebral ischemia in rats and attenuates ischemia-like neuronal damage by inhibiting microglial activation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 131 € | 35 days | |
5 mg | 560 € | 35 days | |
10 mg | 997 € | 35 days | |
25 mg | 2.166 € | 35 days |
Description | HAMI 3379 (HAMI3379) is a selective cysteinyl leukotriene receptor 2 (CysLT2) antagonist that dose- and time-dependently attenuates brain damage and inhibits microglial cell inflammation following focal cerebral ischemia in rats and attenuates ischemia-like neuronal damage by inhibiting microglial activation. |
Targets&IC50 | LTD4:3.8 nM, LTC4:4.4 nM |
In vitro | HAMI 3379 effectively antagonizes LTD4- and LTC4-induced intracellular calcium mobilization in a CysLT2 receptor reporter cell line, with IC50 values of 3.8 nM and 4.4 nM, respectively. In contrast, HAMI 3379 shows minimal potency (IC50 > 10000 nM) in a recombinant CysLT1 receptor cell line and displays no agonistic activity in either CysLT receptor cell line.[1] |
In vivo | 0.025-0.4 mg/kg HAMI 3379, intraperitoneally, was able to significantly reduce infarct volume and decrease the percent increase in the ischemic hemisphere to contralateral hemisphere ratio over the dose range of 0.1-0.4 mg/kg. Administration of 0.1 mg/kg HAMI 3379, intraperitoneal, at 0 and 1 hour after reperfusion was effective in reducing infarct volume, alleviating cerebral edema, decreasing neurologic function scores, and enhancing grip angle. [2] |
Alias | HAMI3379 |
Molecular Weight | 595.72 |
Formula | C34H45NO8 |
Cas No. | 1245653-57-9 |
Smiles | C(N[C@@H]1C[C@@H](C(O)=O)CCC1)(=O)C2=C(OCCCC3=CC=C(OCCCCOC4CCCCC4)C=C3)C=CC(C(O)=O)=C2 |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (134.29 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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