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Montelukast sodium

Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.

Catalog No. T1677LCas No. 151767-02-1

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Purity:99.89%

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COA HNMR HPLC

Montelukast sodium

Catalog No. T1677LCas No. 151767-02-1

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Pack Size	Price	Availability
50 mg	$41	In Stock
100 mg	$66	In Stock
500 mg	$132	In Stock

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Product Introduction

Bioactivity

Description	Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
In vitro	Administering 6 mg/kg of Montelukast once daily for 20 days significantly inhibits the increase of eosinophils in both the BAL fluid and lung tissue in mice stimulated by OVA, while also elevating the IL-5 levels in the BAL fluid. OVA stimulation leads to an upsurge in CysLT1 receptor mRNA expression but a decrease in CysLT2 receptor mRNA expression. Following OVA stimulation, Montelukast suppresses the elevated expression of CysLT1 without diminishing the expression of CysLT2.
In vivo	Montelukast acts by binding to the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, thereby blocking the effects of leukotriene D4. This action prevents airway edema, smooth muscle contraction, and secretion of viscous liquids, reduces bronchoconstriction caused by leukotrienes, and diminishes inflammation occurrence.
Cell Research	Nasal mucosa and polyp epithelial cells are stimulated with fetal bovine serum (FBS) with or without MK for 24 hours, and cytokine concentrations in epithelial secretions are measured by ELISA. After incubating peripheral blood eosinophils with epithelial cell-conditioned media (ECM) with or without montelukast up to 3 days, eosinophil survival is assessed by Trypan blue dye exclusion[1].
Alias	MK0476

Chemical Properties

Molecular Weight	608.17
Formula	C₃₅H₃₅ClNNaO₃S
Cas No.	151767-02-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice.

Solubility Information

H2O: 30.4 mg/mL (50 mM)

DMSO: 55 mg/mL (90.44 mM), The compound is unstable in solution, please use soon.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6443 mL	8.2214 mL	16.4428 mL	82.2139 mL
5 mM	0.3289 mL	1.6443 mL	3.2886 mL	16.4428 mL
10 mM	0.1644 mL	0.8221 mL	1.6443 mL	8.2214 mL
20 mM	0.0822 mL	0.4111 mL	0.8221 mL	4.1107 mL
50 mM	0.0329 mL	0.1644 mL	0.3289 mL	1.6443 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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