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Montelukast sodium
Catalog No. T1677LCas No. 151767-02-1
Alias MK0476
Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
Montelukast sodium
Catalog No. T1677LAlias MK0476Cas No. 151767-02-1
Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $41 | In Stock | |
| 100 mg | $66 | In Stock | |
| 500 mg | $132 | In Stock |
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Purity:99.89%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury. |
| In vitro | Administering 6 mg/kg of Montelukast once daily for 20 days significantly inhibits the increase of eosinophils in both the BAL fluid and lung tissue in mice stimulated by OVA, while also elevating the IL-5 levels in the BAL fluid. OVA stimulation leads to an upsurge in CysLT1 receptor mRNA expression but a decrease in CysLT2 receptor mRNA expression. Following OVA stimulation, Montelukast suppresses the elevated expression of CysLT1 without diminishing the expression of CysLT2. |
| In vivo | Montelukast acts by binding to the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, thereby blocking the effects of leukotriene D4. This action prevents airway edema, smooth muscle contraction, and secretion of viscous liquids, reduces bronchoconstriction caused by leukotrienes, and diminishes inflammation occurrence. |
| Cell Research | Nasal mucosa and polyp epithelial cells are stimulated with fetal bovine serum (FBS) with or without MK for 24 hours, and cytokine concentrations in epithelial secretions are measured by ELISA. After incubating peripheral blood eosinophils with epithelial cell-conditioned media (ECM) with or without montelukast up to 3 days, eosinophil survival is assessed by Trypan blue dye exclusion[1]. |
| Alias | MK0476 |
| Molecular Weight | 608.17 |
| Formula | C35H35ClNNaO3S |
| Cas No. | 151767-02-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 30.4 mg/mL (50 mM) DMSO: 55 mg/mL (90.44 mM), The compound is unstable in solution, please use soon.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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