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MMP-9 Inhibitor I

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Catalog No. T37726Cas No. 206549-55-5

MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.

MMP-9 Inhibitor I

MMP-9 Inhibitor I

😃Good
Catalog No. T37726Cas No. 206549-55-5
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
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Product Introduction

Bioactivity
Description
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
Chemical Properties
Molecular Weight511.63
FormulaC27H33N3O5S
Cas No.206549-55-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 20 mg/mL (39.09 mM), Sonication is recommended.
DMSO: 25 mg/mL (48.86 mM), Sonication is recommended.
Ethanol: 33 mg/mL (64.5 mM), Sonication is recommended.
Ethanol:PBS (pH 7.2) (1:8): 0.11 mg/mL (0.21 mM), Sonication is recommended.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

MMP9 Inhibitor IMMP-9 Inhibitor IMMP 9 Inhibitor I
Related Tags: buy MMP-9 Inhibitor I | purchase MMP-9 Inhibitor I | MMP-9 Inhibitor I cost | order MMP-9 Inhibitor I | MMP-9 Inhibitor I chemical structure | MMP-9 Inhibitor I formula | MMP-9 Inhibitor I molecular weight
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