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MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | $363 | 35 days |
Description | MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM. |
Molecular Weight | 511.63 |
Formula | C27H33N3O5S |
Cas No. | 206549-55-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMF: 20 mg/mL (39.09 mM), Sonication is recommended. DMSO: 25 mg/mL (48.86 mM), Sonication is recommended. Ethanol: 33 mg/mL (64.5 mM), Sonication is recommended. Ethanol:PBS (pH 7.2) (1:8): 0.11 mg/mL (0.21 mM), Sonication is recommended. |
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