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γ-Fibrinogen 377-395 TFA

Name: γ-Fibrinogen 377-395 TFA
Brand: TargetMol
SKU: T80682
Rating: 4.5 (1 reviews)

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Catalog No. T80682

γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Additionally, it exhibits in vivo efficacy by suppressing experimental autoimmune encephalomyelitis (EAE) in mice. This compound has applications in researching multiple sclerosis (MS) and other neuroinflammatory diseases linked to blood-brain barrier disruption and microglial activation [1].

γ-Fibrinogen 377-395 TFA

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Catalog No. T80682

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50 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Additionally, it exhibits in vivo efficacy by suppressing experimental autoimmune encephalomyelitis (EAE) in mice. This compound has applications in researching multiple sclerosis (MS) and other neuroinflammatory diseases linked to blood-brain barrier disruption and microglial activation [1].
In vitro	γ-Fibrinogen377-395 TFA (200 μM) inhibits the binding of fibrinogen to Mac-1, reducing the adhesion of Mac-1 overexpressing cells to immobilized fibrinogen and suppressing microglial activation [1].
In vivo	Administration of γ-Fibrinogen377-395 TFA (30 μg/mouse; intranasal; once daily for 40 days) enhanced motor function in mice without affecting peripheral immune responses. γ-Fibrinogen377-395 did not alter the coagulation properties of fibrinogen [1]. Mice immunized with γ377-395 peptide prior to EAE induction exhibited improved motor strength and coordination compared to the control group [1].

Chemical Properties

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc