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γ-Fibrinogen 377-395
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γ-Fibrinogen 377-395
Catalog No. T80683Cas No. 957792-67-5
γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimental autoimmune encephalomyelitis (EAE) in murine models in vivo. This compound is relevant for research into multiple sclerosis (MS) and other neuroinflammatory disorders characterized by blood-brain barrier compromise and microglial activation [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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| Description | γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimental autoimmune encephalomyelitis (EAE) in murine models in vivo. This compound is relevant for research into multiple sclerosis (MS) and other neuroinflammatory disorders characterized by blood-brain barrier compromise and microglial activation [1]. |
| In vitro | The compound γ-Fibrinogen377-395 at a concentration of 200 μM inhibits the binding of fibrinogen to Mac-1, thereby reducing the adhesion of Mac-1 overexpressing cells to immobilized fibrinogen. Additionally, γ-Fibrinogen377-395 suppresses the activation of microglia [1]. |
| In vivo | γ-Fibrinogen377-395 (30 μg/mouse; intranasal administration; once daily for 40 days) enhanced motor function in mice without affecting peripheral immune responses. γ-Fibrinogen377-395 did not alter the coagulation properties of fibrinogen [1]. Mice immunized with the γ377-395 peptide before EAE induction displayed improved motor strength and coordination compared to the control group [1]. |
| Molecular Weight | 2229.66 |
| Formula | C100H165N25O28S2 |
| Cas No. | 957792-67-5 |
| Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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