Anti-Alzheimer's Disease Compound Library

Catalog No. L9840

Library Compound List Excel SDF

Alzheimer's disease (AD) is a progressive neurodegenerative disease with deficits in recent memory, wordfinding, and language difficulties, and gradually progresses to global cognitive impairment. The cognitive deficits are accompanied by a variety of abnormal neurological and psychiatric symptoms that increase in frequency and severity as the disease progresses. The cause of Alzheimer’s disease is unknown but the fifth-leading cause of death among those age 65 and older. The pathological features of AD mainly include cholinergic dysfunction, extracellular accumulation and deposition of Aβ peptides, intracellular neurofibrillary tangles, and other aberrant signaling pathways. Scientists have found that reducing brain Aβ levels, preventing the excessive phosphorylation of tau protein, rendering mitochondria resistant to damage, protecting neurons from apoptotic processes, controlling microglial activation, inhibiting the release of interleukin-2 and TNF-α, preventing oxidative stress damage; regulating the targets in cholinergic system, inhibiting the over activation of NMDA receptor to reduce the excitotoxicity can halt Alzheimer's disease.

Although Alzheimer’s disease (AD) is the world’s leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Over the past decade, the focus of drug discovery and development efforts has shifted from symptom improving toward disease-modifying therapies for AD; that is, treatments whose aim is to affect the underlying disease process by impacting one or more of the many brain changes characteristic of AD. Many clinical trials of single-agent therapies have failed to affect disease progression or symptoms compared with placebo. The complex pathophysiology of AD may necessitate combination treatments rather than monotherapy. In addition, small molecules targeting neural stem cells (NSCs) regeneration represents a new drug discovery strategy.

TargetMol’s Anti-Alzheimer’s Disease Compound Library, a collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD, can be used for related drug discovery and pharmacology research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.
Targets include tau protein, γ Secretase, 5-HT Receptor, BACE, etc.
Some of them are FDA approved.?
Structurally diverse, medicinally active, and cell permeable;
Detailed information about compound structure, target, activity, IC50, etc.
NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Adrenergic Receptor (184)

AChR (179)

5-HT Receptor (142)

Dopamine Receptor (86)

PDE (58)

GABA Receptor (54)

NMDAR (46)

Beta Amyloid (33)

GSK-3 (30)

GluR (29)

Gamma-secretase (24)

PPAR (23)

Histamine Receptor (21)

Norepinephrine (19)

Potassium Channel (14)

MAO (13)

Sodium Channel (11)

Calcium Channel (10)

CDK (10)

BACE (10)

P450 (9)

NF-κB (8)

Adenosine Receptor (8)

TNF (8)

Cannabinoid Receptor (7)

COX (6)

EGFR (5)

c-Kit (5)

Endogenous Metabolite (5)

Opioid Receptor (5)

Estrogen/progestogen Receptor (5)

Antifection (5)

JNK (5)

Antioxidant (5)

Microtubule Associated (5)

CaMK (4)

Autophagy (4)

Caspase (4)

Tyrosinase (4)

Epigenetic Reader Domain (4)

IL Receptor (4)

HDAC (4)

Src (4)

Dehydrogenase (4)

ERK (3)

MEK (3)

HMG-CoA Reductase (3)

Transferase (3)

Serotonin Transporter (3)

iGluR (3)

CCR (3)

PKA (3)

Amino Acids and Derivatives (3)

VEGFR (3)

Sirtuin (3)

BCL (3)

Trk receptor (2)

LDL (2)

p38 MAPK (2)

TRP/TRPV Channel (2)

Integrin (2)

Immunology & Inflammation related (2)

Vitamin (2)

Wnt/beta-catenin (2)

IκB/IKK (2)

MRP (2)

TGF-beta/Smad (2)

MMP (2)

Sigma receptor (2)

mTOR (2)

NADPH (2)

Retinoid Receptor (2)

Raf (2)

NOD (2)

PKC (2)

Nrf2 (2)

PI3K (2)

Phospholipase (2)

PARP (2)

HIV Protease (2)

AChE (2)

Antibiotic (2)

Carbonic Anhydrase (2)

cAMP (2)

Chloride channel (2)

CSF-1R (2)

Aurora Kinase (2)

FLT (2)

Antiviral (2)

Glucocorticoid Receptor (2)

Casein Kinase (2)

HIF (2)

AMPK (2)

advanced glycation end products (2)

transporter (1)

S6 Kinase (1)

ABC (1)

Acyltransferase (1)

Adenylyl cyclase (1)

BTK (1)

Beta-Secretase (1)

Prostaglandin Receptor (1)

Bcr-Abl (1)

Adiponectin receptor (1)

Reverse Transcriptase (1)

Rho (1)

UGT (1)

ATPase (1)

Androgen Receptor (1)

ATM/ATR (1)

Aromatase (1)

Akt (1)

c-Fms (1)

STAT (1)

Telomerase (1)

TLR (1)

Annexin A (1)

Topoisomerase (1)

Transaminase (1)

Antifungal (1)

IGF-1R (1)

Phosphatase (1)

Liver X Receptor (1)

Monoamine Transporter (1)

GPR (1)

Mitochondrial Metabolism (1)

GRK (1)

GST (1)

Hck (1)

Lipoxygenase (1)

GlyT (1)

HCV Protease (1)

Keap1-Nrf (1)

HER (1)

Histone Acetyltransferase (1)

Histone Demethylase (1)

Histone Methyltransferase (1)

Monocarboxylate transporter (1)

MT Receptor (1)

P-gp (1)

Cysteine Protease (1)

IAP (1)

CGRP Receptor (1)

Parasite (1)

PAFR (1)

p53 (1)

cholecystokinin (1)

Ferroptosis (1)

Glucokinase (1)

Nucleoside Antimetabolite/Analog (1)

FGFR (1)

NOS (1)

FXR (1)

Gap Junction Protein (1)

GluCls (1)

PDGFR (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty