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Anti-Alzheimer's Disease Compound Library

Catalog No. L9840
  Library Compound List   Excel SDF

Alzheimer's disease (AD) is a progressive neurodegenerative disease with deficits in recent memory, wordfinding, and language difficulties, and gradually progresses to global cognitive impairment. The cognitive deficits are accompanied by a variety of abnormal neurological and psychiatric symptoms that increase in frequency and severity as the disease progresses. The cause of Alzheimer’s disease is unknown but the fifth-leading cause of death among those age 65 and older. The pathological features of AD mainly include cholinergic dysfunction, extracellular accumulation and deposition of Aβ peptides, intracellular neurofibrillary tangles, and other aberrant signaling pathways. Scientists have found that reducing brain Aβ levels, preventing the excessive phosphorylation of tau protein, rendering mitochondria resistant to damage, protecting neurons from apoptotic processes, controlling microglial activation, inhibiting the release of interleukin-2 and TNF-α, preventing oxidative stress damage; regulating the targets in cholinergic system, inhibiting the over activation of NMDA receptor to reduce the excitotoxicity can halt Alzheimer's disease. 

Although Alzheimer’s disease (AD) is the world’s leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Over the past decade, the focus of drug discovery and development efforts has shifted from symptom improving toward disease-modifying therapies for AD; that is, treatments whose aim is to affect the underlying disease process by impacting one or more of the many brain changes characteristic of AD. Many clinical trials of single-agent therapies have failed to affect disease progression or symptoms compared with placebo. The complex pathophysiology of AD may necessitate combination treatments rather than monotherapy. In addition, small molecules targeting neural stem cells (NSCs) regeneration represents a new drug discovery strategy.

TaregtMol’s Anti-Alzheimer’s Disease Compound Library, a collection of 1040 compounds with anti-AD activities or acting on main drug targets of PD, can be used for related drug discovery and pharmacology research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.
  • Targets include tau protein, γ Secretase, 5-HT Receptor, BACE, etc.
  • Some of them are FDA approved. 
  • Structurally diverse, medicinally active, and cell permeable;
  • Detailed information about compound structure, target, activity, IC50, etc.
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L9840)

Library Composition

Adrenergic Receptor (184)
AChR (179)
5-HT Receptor (142)
Dopamine Receptor (86)
PDE (58)
GABA Receptor (54)
NMDAR (46)
Beta Amyloid (33)
GSK-3 (30)
GluR (29)
Gamma-secretase (24)
PPAR (23)
Histamine Receptor (21)
Norepinephrine (19)
Potassium Channel (14)
MAO (13)
Sodium Channel (11)
Calcium Channel (10)
CDK (10)
BACE (10)
P450 (9)
NF-κB (8)
Adenosine Receptor (8)
TNF (8)
Cannabinoid Receptor (7)
COX (6)
EGFR (5)
c-Kit (5)
Endogenous Metabolite (5)
Opioid Receptor (5)
Estrogen/progestogen Receptor (5)
Antifection (5)
JNK (5)
Antioxidant (5)
Microtubule Associated (5)
CaMK (4)
Autophagy (4)
Caspase (4)
Tyrosinase (4)
Epigenetic Reader Domain (4)
IL Receptor (4)
HDAC (4)
Src (4)
Dehydrogenase (4)
ERK (3)
MEK (3)
HMG-CoA Reductase (3)
Transferase (3)
Serotonin Transporter (3)
iGluR (3)
CCR (3)
PKA (3)
Amino Acids and Derivatives (3)
VEGFR (3)
Sirtuin (3)
BCL (3)
Trk receptor (2)
LDL (2)
p38 MAPK (2)
TRP/TRPV Channel (2)
Integrin (2)
Immunology & Inflammation related (2)
Vitamin (2)
Wnt/beta-catenin (2)
IκB/IKK (2)
MRP (2)
TGF-beta/Smad (2)
MMP (2)
Sigma receptor (2)
mTOR (2)
NADPH (2)
Retinoid Receptor (2)
Raf (2)
NOD (2)
PKC (2)
Nrf2 (2)
PI3K (2)
Phospholipase (2)
PARP (2)
HIV Protease (2)
AChE (2)
Antibiotic (2)
Carbonic Anhydrase (2)
cAMP (2)
Chloride channel (2)
CSF-1R (2)
Aurora Kinase (2)
FLT (2)
Antiviral (2)
Glucocorticoid Receptor (2)
Casein Kinase (2)
HIF (2)
AMPK (2)
advanced glycation end products (2)
transporter (1)
S6 Kinase (1)
ABC (1)
Acyltransferase (1)
Adenylyl cyclase (1)
BTK (1)
Beta-Secretase (1)
Prostaglandin Receptor (1)
Bcr-Abl (1)
Adiponectin receptor (1)
Reverse Transcriptase (1)
Rho (1)
UGT (1)
ATPase (1)
Androgen Receptor (1)
ATM/ATR (1)
Aromatase (1)
Akt (1)
c-Fms (1)
STAT (1)
Telomerase (1)
TLR (1)
Annexin A (1)
Topoisomerase (1)
Transaminase (1)
Antifungal (1)
IGF-1R (1)
Phosphatase (1)
Liver X Receptor (1)
Monoamine Transporter (1)
GPR (1)
Mitochondrial Metabolism (1)
GRK (1)
GST (1)
Hck (1)
Lipoxygenase (1)
GlyT (1)
HCV Protease (1)
Keap1-Nrf (1)
HER (1)
Histone Acetyltransferase (1)
Histone Demethylase (1)
Histone Methyltransferase (1)
Monocarboxylate transporter (1)
MT Receptor (1)
P-gp (1)
Cysteine Protease (1)
IAP (1)
CGRP Receptor (1)
Parasite (1)
PAFR (1)
p53 (1)
cholecystokinin (1)
Ferroptosis (1)
Glucokinase (1)
Nucleoside Antimetabolite/Analog (1)
FGFR (1)
NOS (1)
FXR (1)
Gap Junction Protein (1)
GluCls (1)
PDGFR (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE