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Cancer is a serious disease caused by the unrestricted proliferation of cells in the body that lose normal growth control. It can occur in any part of the body, such as the lungs, breasts, colon, and skin. Cancer is one of the major threats to global health, causing millions of deaths each year and bringing profound pain and economic burdens to patients and their families. In recent years, there has been significant progress in the field of cancer treatment, especially in areas such as targeted therapy and immunotherapy. Researchers are working hard to discover new biomarkers and treatment methods to further improve treatment effectiveness.
In this critical field, our company can provide comprehensive solutions to support the research and development of anti-cancer drugs . We have a variety of inhibitors and activators targeting popular oncological targets, such as KRAS inhibitors (MRTX1133, BI-2493, Sotorasib), ferroptosis inhibitors (Ferrostatin-1, iFSP1, Deferoxamine, Mesylate), and ferroptosis activators (Erastin, FIN56, Sorafenib), etc. We also offer a wide range of specialized compound libraries covering a broad spectrum of chemical structures and biological activities to support the discovery and screening process of anti-cancer drugs, such as anti-cancer drug library, ferroptosis compound library, Epigenetics Compound Library, DNA damage & repair compound library, etc. In addition, we provide anti-cancer drug screening services, including virtual screening, molecular docking, and active screening of physical compounds. Combining advanced technology and extensive experience, we can help researchers effectively identify and optimize potential anti-cancer drug candidates
Popular targets recommendations
EGFR
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
293 Products
HER
The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.
60 Products
VEGF
Vascular endothelial growth factor (VEGF) is a signal protein produced by many cells that stimulates the formation of blood vessels. In mammals, the VEGF family comprises five members: VEGF-A, placenta growth factor (PGF), VEGF-B, VEGF-C and VEGF-D. All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. They are important signaling proteins involved in both vasculogenesis and angiogenesis.
33 Products
RAF
RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma. RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases.
98 Products
RAS
Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
100 Products
PI3K
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.
289 Products
mTOR
The mammalian target of rapamycin (mTOR), sometimes also referred to as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.
141 Products
PD-1/PD-L1
The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.
59 Products
Bcr-Abl
The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.
60 Products
ALK
Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
73 Products
c-Met/HGFR
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing.
96 Products
CD38
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
7 Products
Popular compound libraries recommendations
Anti-Cancer Drug Library
Listed in literature
L21503159 Compounds
A unique collection of 3159 anticancer drugs for high throughput screening (HTS) and high content screening (HCS);
Listed in literatureDNA Damage & Repair Compound Library Listed in literature
L3900937 Compounds
A unique collection of 937 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Listed in literatureEpigenetics Compound Library Listed in literature
L1200960 Compounds
Well-chosen 960 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs;
Listed in literatureCell Cycle Compound Library Listed in literature
L8100695 Compounds
A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);
Listed in literatureFerroptosis Compound Library Listed in literature
L8700800 Compounds
A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
Listed in literatureChemotherapy Drug Library Listed in literature
L215151 Compounds
51 Chemotherapeutic drugs that can be used for high-throughput and high-content screening.
Listed in literature- TOP
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