Shopping Cart

Remove All
Your shopping cart is currently empty

Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.

Filter HomeSignaling PathwaysImmunology/InflammationNO Synthase

5,7,8-Trimethoxyflavone

TN199523050-38-6

5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) is a compound extracted from *Andrographis paniculata*, exhibiting anti-inflammatory activity and NO inhibition.

In Stock

Size

QTY

FK-330 dihydrate

T68879682813-92-9In house

FK-330 dihydrate (FR-260330 dihydrate) is a novel and effective nitric oxide synthase inhibitor. It can prevent ischemia and reperfusion injury in rat liver transplantation.

$397

In Stock

Size

QTY

Ginsenoside C-K

T381139262-14-1

Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.

$110

In Stock

Size

QTY

Mifepristone

T110284371-65-3

Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.

In Stock

Size

QTY

Atranorin

TN1413479-20-9

Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotective effects on cells under oxidative

In Stock

Size

QTY

Glabrol

TN169159870-65-4

5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.

In Stock

Size

QTY

Prim-O-glucosylcimifugin

T380580681-45-4

Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0 G1 phase.

In Stock

Size

QTY

Quercimeritrin

TN1041491-50-9

Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) has antibacterial activity, it shows promising activity against Staphylococcus aureus.

In Stock

Size

QTY

Asperuloside

T384714259-45-1

Asperuloside (Asperulosid) has anti-inflammatory activity.

In Stock

Size

QTY

NG,NG-dimethyl-L-Arginine dihydrochloride

T21546220805-22-1

NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].

In Stock

Size

QTY

Hydrangenol

TN4234480-47-7In house

Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation.

$139

In Stock

Size

QTY

L-NAME hydrochloride

T657051298-62-5

L-NAME hydrochloride (L-NAME HCl), a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively.

In Stock

Size

QTY

Nitrosoglutathione

T1993057564-91-7

Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.

In Stock

Size

QTY

Methylene Blue

T688861-73-4

Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.

In Stock

Size

QTY

Cited

Chondroitin sulfate

T29809007-28-7

Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition

In Stock

Size

QTY

Cited

Taraxasterol

T37701059-14-9

Taraxasterol (Taraxasterin) is compound with anti-inflammatory activity.

In Stock

Size

QTY

S-Nitroso-N-acetyl-DL-penicillamine

T1280867776-06-1

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.

In Stock

Size

QTY

AVE-9488

T30219291756-32-6

AVE-9488 is a novel endothelial NO synthase (eNOS) enhancer that upregulates eNOS expression, induces NO production, and may ameliorate portal hypertension.

$293

In Stock

Size

QTY

Isosorbide dinitrate

T147987-33-2

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

In Stock

Size

QTY

7-Ethoxyresorufin

T215075725-91-7

7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate and competitive inhibitor of cytochrome P450, particularly CYP1A1.

In Stock

Size

QTY

Tat-NR2B9c

T13112500992-11-0

Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxidase in neurons, thereby blocking the production of superoxide, which reduces ischemic injury in the acute phase after stroke.

In Stock

Size

QTY

DETA NONOate

T36033146724-94-9

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infected wounds.

In Stock

Size

QTY

Nitro blue tetrazolium chloride

T19032298-83-9

Nitro blue tetrazolium chloride (NBT), an NADPH-diaphorase substrate (IC50 = 3-4 M) and well-known scavenger of superoxide anions, competitively inhibits nitric oxide synthase. Additionally, NBT, as a substrate for dehydrogenases, is used with the alkaline phosphatase substrate BCIP in western blotting and immunohistological staining procedures.

In Stock

Size

QTY

Regaloside B

TN2139114420-67-6

Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2).

In Stock

Size

QTY

Isoscoparin

TN180320013-23-4

Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and treatment of obesity.

In Stock

Size

QTY

Catalposide

TN36096736-85-2

Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties.

$228

In Stock

Size

QTY

Myristicin

T9113607-91-0

Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin can induce Apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, Caspase-3 activation, PARP-cleavage and DNA fragmentation.

In Stock

Size

QTY

Pelargonidin chloride

TN1058134-04-3

Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1 Nrf2 signaling pathway.

In Stock

Size

QTY

Asymmetric dimethylarginine

T768230315-93-6

Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide.

In Stock

Size

QTY

Gardenin B

TN16752798-20-1

Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .

In Stock

Size

QTY

Protosappanin A

TJS1779102036-28-2

Protosappanin A (PTA) has anti-oxidative nitrative activities on brain immune and neuroinflammation through regulation of CD14 TLR4-dependent IKK IÎºB NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

In Stock

Size

QTY

Isoquercetin

T5S0754482-35-9

1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercetin is an inhibitor of Wnt β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .

In Stock

Size

QTY

Cited

Tsugaric acid A

TN2286174391-64-1

Tsugaric acid A significantly inhibits superoxide anion formation in fMLP CB-stimulated rat neutrophils and protects human keratinocytes against damage induced by ultraviolet B (UV B) light, indicating that tsugaric acid A can safeguard keratinocytes from photodamage.

In Stock

Size

QTY

Aminoguanidine hydrochloride

T03581937-19-5

Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.

In Stock

Size

QTY

Cited

Harpagoside

T6S202319210-12-9

1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression of cyclooxygenase-2 and inducible

In Stock

Size

QTY

Tirucallol

TN1006514-46-5

Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.

Backorder

Size

QTY

Cnidicin

TN151614348-21-1

Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor

$153

In Stock

Size

QTY

anemarsaponin B

T7030139051-27-7

Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B can inhibit PAF-induced rabbit platelet aggregation in vitro.

In Stock

Size

QTY

NOC-5

T35969146724-82-5

NOC-5 is an NO donor that induces airway relaxation and concentration-dependently triggers 10 μM DAF-2 fluorescence.

In Stock

Size

QTY

Methylene Blue trihydrate

T00067220-79-3

Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).

In Stock

Size

QTY

Secologanic acid

TN102160077-46-5

Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages.

$121

In Stock

Size

QTY

6-Biopterin

T759722150-76-1

6-Biopterin (L-Biopterin) is a natural product,is a NO synthase cofactor.

In Stock

Size

QTY

Kaempferol 3,7,4'-trimethyl ether

TN181715486-34-7

Kaempferol 3,7,4'-trimethyl ether (Kaempferol 3,7,4'-trimethylether) demonstrates selective cytotoxic activities against nine tested cancer cell lines.

$122

In Stock

Size

QTY

2,4-Diamino-6-hydroxypyrimidine

T746156-06-4

2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis

In Stock

Size

QTY

Cited

Dactylorhin A

TN1546256459-34-4

Dactylorhin A, a succinate derivative ester isolated from the rhizomes of Gymnadenia conopsea, exhibits a moderate inhibitory effect on nitric oxide (NO) production in RAW 264.7 macrophage cells.

In Stock

Size

QTY

Piceatannol 3'-O-glucoside

T3S040194356-26-0

Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.

In Stock

Size

QTY

4-Hydroxyflavanone

T79926515-37-3

4-Hydroxyflavanone is a natural product, shows full vasorelaxing effects

In Stock

Size

QTY

3,4-O-Isopropylidene-shikimic acid

TN1238183075-03-8

3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) exhibits significant anti-inflammatory, anti-thrombosis, antioxidant, and analgesic effects, and provides protective benefits against trinitrobenzenesulfonic acid-induced experimental colitis in rats, likely because of its antioxidant properties.

In Stock

Size

QTY

Go to page 1

Page of 3