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2-Thiouracil

Catalog No. T1310Cas No. 141-90-2
Alias Thiouracil, Deracil

2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.

2-Thiouracil

2-Thiouracil

Purity: 99.33%
Catalog No. T1310Alias Thiouracil, DeracilCas No. 141-90-2
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
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1 g$29In Stock
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Purity:99.33%
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Product Introduction

Bioactivity
Description
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
Targets&IC50
nNOS:20 μM (Ki)
In vivo
2-Thiouracil is a selective neuronal nitric oxide synthase inhibitor capable of antagonizing tetrahydrobiopterin-dependent enzymatic activation.
AliasThiouracil, Deracil
Chemical Properties
Molecular Weight128.15
FormulaC4H4N2OS
Cas No.141-90-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (429.18 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM7.8034 mL39.0168 mL78.0336 mL390.1678 mL
5 mM1.5607 mL7.8034 mL15.6067 mL78.0336 mL
10 mM0.7803 mL3.9017 mL7.8034 mL39.0168 mL
20 mM0.3902 mL1.9508 mL3.9017 mL19.5084 mL
50 mM0.1561 mL0.7803 mL1.5607 mL7.8034 mL
100 mM0.0780 mL0.3902 mL0.7803 mL3.9017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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