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Resmetirom
🥰Excellent
Catalog No. T3595Cas No. 920509-32-6
Alias VIA-3196, MGL3196
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
Resmetirom
🥰Excellent
Purity: 100%
Catalog No. T3595Alias VIA-3196, MGL3196Cas No. 920509-32-6
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 2 mg | $47 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $225 | In Stock | |
| 50 mg | $360 | In Stock | |
| 100 mg | $535 | In Stock | |
| 500 mg | $1,190 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $84 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist. |
| Targets&IC50 | THRβ:0.21 μM(EC50) |
| In vitro | Resmetiromis 28-fold selective for THR-β (EC50=0.21 μM) over THR-α (EC50=3.74 μM ) in a functional assay. Resmetiromshows an IC20 of roughly 30 μM for blockage of the hERG channel. The IC50 for CYP3A4/5 and for CYP2C19 is >50 μM, and there is only weak inhibition (roughly 22 μM) of CYP2C9[1]. |
| In vivo | MGL-3196 demonstrates favorable exposures and acceptable oral bioavailability in rats, with both the volume of distribution and clearance being low. When administered orally to DIO mice, MGL-3196 in a suspension form shows dose-dependent increases in exposure[1]. Treatment with MGL-3196 leads to decreased cholesterol levels and liver size, attributed to the reduction of liver triglycerides (TG). Importantly, no impact is observed on bone mineral density (BMD), or the size of the heart or kidneys in animals receiving MGL-3196[1]. |
| Alias | VIA-3196, MGL3196 |
| Molecular Weight | 435.22 |
| Formula | C17H12Cl2N6O4 |
| Cas No. | 920509-32-6 |
| Smiles | CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O |
| Relative Density. | 1.65 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (137.86 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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