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MAHMA NONOate
🥰Excellent
Catalog No. T74030Cas No. 146724-86-9
MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
MAHMA NONOate
🥰Excellent
Catalog No. T74030Cas No. 146724-86-9
MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation. |
| In vitro | MAHMA NONOate (0.1 nM - 100 μM) induces concentration-dependent inhibition of collagen or ADP-induced platelet aggregation, but its potency as an aggregation inhibitor is inferior to its potency as a pulmonary vasodilator [1]. |
| In vivo | Intravenous injection of MAHMA NONOate (0.3-10 nmol/kg/min; once) in pentobarbital-anesthetized male Wistar rats led to dose-dependent decreases in mean systemic arterial pressure, proving more effective than GSNO, and also caused dose-dependent inhibition of the response to 0.3 μM/kg ADP[2]. |
| Molecular Weight | 204.27 |
| Formula | C8H20N4O2 |
| Cas No. | 146724-86-9 |
| Smiles | O=NN(O)N(C)CCCCCCNC |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 40 mg/mL (195.82 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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