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iNOS inhibitor-10
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Catalog No. T72638Cas No. 2918773-63-2
iNOS Inhibitor-10, with an IC50 of 65 nM, exhibits antiproliferative effects on triple-negative breast cancer cells [1].
iNOS inhibitor-10
😃Good
Catalog No. T72638Cas No. 2918773-63-2
iNOS Inhibitor-10, with an IC50 of 65 nM, exhibits antiproliferative effects on triple-negative breast cancer cells [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | iNOS Inhibitor-10, with an IC50 of 65 nM, exhibits antiproliferative effects on triple-negative breast cancer cells [1]. |
| Targets&IC50 | eNOS:>50 μM, iNOS:0.065 μM |
| In vitro | iNOS inhibitor-10 at a concentration of 1 μM suppresses iNOS activity by 83% while remaining inactive against eNOS [1]. The same inhibitor, ranging from 0.001 to 100 μM over a period of 5 days, diminishes the viability of MDA-MB-231 cells [1]. Furthermore, at 25 μM for 24 hours, it impedes the migration of MDA-MB-231 cells [1]. Tested in liver microsomes, iNOS inhibitor-10 displays moderate metabolic stability, evidenced by a half-life (t1/2) of 38 minutes and an intrinsic clearance (CLint) of 39.6 mL/min/Kg [1]. |
| Molecular Weight | 393.5 |
| Formula | C22H23N3O2S |
| Cas No. | 2918773-63-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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