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Tat-NR2B9c

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Purity:99.97%

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COA HPLC MS

Tat-NR2B9c

Catalog No. T13112Cas No. 500992-11-0

Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxidase in neurons, thereby blocking the production of superoxide, which reduces ischemic injury in the acute phase after stroke.

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Pack Size	Price	Availability	Quantity
1 mg	$99	In Stock

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Product Introduction

Bioactivity

Description	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxidase in neurons, thereby blocking the production of superoxide, which reduces ischemic injury in the acute phase after stroke.
In vitro	Similar to the NR2 subunits, Tat-NR2B9c binds to PSD-95d1 and PSD-95d2, and this binding is independent of PDZ interactions, with respective ED50 values of 0.67 μM and 0.067 μM[2].
In vivo	Tat-NR2B9c (10 nmol/g, IV) reduced infarct volume by 24.5% and 26.0% following 30 and 60 minutes of tMCAO, respectively, but had no effect on mice at a dose of 3 nM/g[3].
Alias	Tat-NR2Bct, NA-1

Chemical Properties

Molecular Weight	2518.88
Formula	C105H188N42O30
Cas No.	500992-11-0

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 80 mg/mL (224.57 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.3970 mL	1.9850 mL	3.9700 mL	19.8501 mL
5 mM	0.0794 mL	0.3970 mL	0.7940 mL	3.9700 mL
10 mM	0.0397 mL	0.1985 mL	0.3970 mL	1.9850 mL
20 mM	0.0199 mL	0.0993 mL	0.1985 mL	0.9925 mL
50 mM	0.0079 mL	0.0397 mL	0.0794 mL	0.3970 mL
100 mM	0.0040 mL	0.0199 mL	0.0397 mL	0.1985 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc