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Grasshopper ketone
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Catalog No. TN5387Cas No. 41703-38-2
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation.
Grasshopper ketone
😃Good
Catalog No. TN5387Cas No. 41703-38-2
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,698 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $2,038 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation. |
| In vitro | Grasshopper ketone (100 μg/ml) is not cytotoxic to RAW 264.7, and is an effective inhibitor of LPS-induced NO production in RAW 264.7 cells.[1] Grasshopper ketone (0.1-100 μg/ml) significantly reduced pro-inflammatory cytokines, including IL-6, IL-1β, and TNF-α (p<0.05). We confirmed the dose-dependent and significant inhibition of iNOS and COX-2 protein expression.[1] Grasshopper ketone (0.1, 1, 10, 50, and 100 μg/ml,) was found to significantly decrease IFN-γ and IL-4 production in concanavalin A-stimulated splenocytes from BALB/c mice with no cytotoxicity.[3] |
| Molecular Weight | 224.3 |
| Formula | C13H20O3 |
| Cas No. | 41703-38-2 |
| Smiles | [C@](=CC(C)=O)=C1C(C)(C)C[C@H](O)C[C@@]1(C)O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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