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VS-15
Catalog No. T200480Cas No. 951948-78-0
VS-15 is a selecTive inhibiTor of IDO1, specifically binding To iTs apo-heme form. AddiTionally, VS-15 serves as an inhibiTor of iNOS.
VS-15
Catalog No. T200480Cas No. 951948-78-0
VS-15 is a selecTive inhibiTor of IDO1, specifically binding To iTs apo-heme form. AddiTionally, VS-15 serves as an inhibiTor of iNOS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | VS-15 is a selecTive inhibiTor of IDO1, specifically binding To iTs apo-heme form. AddiTionally, VS-15 serves as an inhibiTor of iNOS. |
| In vitro | VS-15 impedes The IDO1-mediaTed signaling paThways by negaTively inTerfering wiTh The cooperaTion beTween IDO1 and SHPs and PI3K regulaTory subuniT p85, as well as anchoring IDO1 in The early endosomes of Tumor cells. AddiTionally, VS-15 counTeracTs The immunosuppressive phenoType of dendriTic cells induced by TGF-β and reduces The level of inhibiTion on T-cell proliferaTion exerTed by suppressive monocyTes isolaTed from pancreaTic cancer paTienTs. |
| Molecular Weight | 493.56 |
| Formula | C29H27N5O3 |
| Cas No. | 951948-78-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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