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3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
Catalog No. TN1109Cas No. 168293-14-9
Alias 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) exhibits anti-inflammatory activity by inhibiting NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
Catalog No. TN1109Alias 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acidCas No. 168293-14-9
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) exhibits anti-inflammatory activity by inhibiting NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $100 | Backorder | |
| 5 mg | $480 | Backorder |
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Product Introduction
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Chemical Properties
| Description | 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) exhibits anti-inflammatory activity by inhibiting NO production and iNOS expression in LPS-stimulated Raw264.7 cells. |
| In vitro | Based on bioassay-guided fractionation using lipopolysaccharide (LPS)-stimulated Raw264.7 cells, chemical investigation of the EtOH extract of the sclerotia of P. cocos resulted in the isolation and identification of eight compounds including six triterpenoids, namely poricoic acid A (1), 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid(2), polyporenic acid C (3), 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid (4), trametenolic acid (5), and dehydroeburicoic acid (6), as well as (-)-pinoresinol (7) and protocatechualdehyde (8). The structures of the isolated compounds were determined by spectroscopic analysis, including 1H and 13C NMR spectra, and LC/MS analysis. The anti-inflammatory activities of the isolates were evaluated by estimating their effect on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated Raw264.7 as well as on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Compounds 1-5 inhibited NO production and iNOS expression in LPS-stimulated Raw264.7 cells. Among them, compound 1 exerted the highest anti-inhibitory activity and reduced PGE2 levels via downregulation of COX-2 protein expression. |
| Alias | 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid |
| Molecular Weight | 512.72 |
| Formula | C32H48O5 |
| Cas No. | 168293-14-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid3-O-Acetyl-16a-hydroxydehydrotrametenolic acidtriterpenoidiNOSNO SynthaseproductionNOS3-O-Acetyl-16 a-hydroxydehydrotrametenolic acidinhibitNitric oxide synthases3-O-Acetyl-16 α-hydroxydehydrotrametenolic acidInhibitorRaw264.7anti-inflammatory3OAcetyl16αhydroxydehydrotrametenolic acid3 O Acetyl 16α hydroxydehydrotrametenolic acid
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