triterpenoid

Limonin (Citrolimonin) is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.

beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.

Hederagenin (Hederagenol) is a triterpenoid saponin inhibiting LPS-stimulated expression of iNOS, COX-2, and NF-κB.

Acetyl 11α-methoxy-β-boswellic Acid is a triterpenoid extracted from frankincense resin.

1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 + - .3 microM.

Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By suppressing reactive oxygen and nitrogen species (ROS RNS) formation, it promotes the cellular control of ROS RNS levels that would lead to DNA damage associated with tumorigenesis. In various Y cell lines, Bardoxolone has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that Bardoxolone is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.

Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.

Celosin H is a novel hepatoprotective triterpenoid saponin isolated from the methanol extract of Celosiae Semen.

Mogroside IV-E is a triterpenoid glycoside isolated from the extracts of Luo Han Guo. Mogrosides exhibit antidiabetic, antioxidant and anticancer activities.

Pulchinenoside C (Anemoside B4) is an abundant triterpenoid saponin isolated from P. chinensis, exhibiting significant anti-inflammatory and antioxidant properties.

Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae, widely used in East Asian countries for treating inflammation-related diseases.

Mogroside IIe is a bitter triterpenoid saponin which is the main component of unripe Luo Han Guo fruit and a precursor of the commercially available sweetener mogroside V.

Hederagenin-28-beta-D-glucopyranoside, a triterpenoid saponin isolated from Ilex cornuta, protects against H2O2-induced damage in cardiomyocytes.

Rosamultin has antioxidant, antiinflammatory antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.

Sericoside, a triterpenoid compound, is obtained from Terminalia and exhibits potent anti-inflammatory properties. Additionally, sericoside displays robust lipolytic activity, thereby aiding in the reduction of skin wrinkles and improvement of skin texture.

Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1].

Acanthopanaxoside A, a triterpenoid saponin, demonstrates inhibitory activity against pancreatic lipase [1].

12β-Acetoxyganoderic Acid θ, a triterpenoid extracted from G. lucidum [1], exhibits potential biological activities.

25-Deacetylcucurbitacin A, a cucurbitane-type triterpenoid, has potential as an anti-cancer agent and JAK STAT3 signaling pathway inhibitor [1].

Platycoside F, a triterpenoid saponin compound, can be isolated from the roots of Platycodon grandiflorum [1].

Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) cell lines and ameliorates collagen-induced arthritis in mice [1] [2].

15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid is a Lanostane triterpenoid that inhibits NO production in LPS-induced microglia.

Tetrahymanol is a cyclic triterpenoid present in Tetrahymena pyriformis and marine sediments that does not require molecular oxygen.

Betulone is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane.

Gylongipolactone A is a natural triterpenoid compound.

Bryononic acid is a new cucurbitane-type triterpenoid. Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.

Dehydroeburicoic acid monoacetate (3-O-Acetyldehydroeburicoic acid) is a triterpenoid of lanolin isolated from Wolfiporia cocos.

Poricoic acid AM is a triterpenoid compound derived from Poria cocos, exhibiting anti-tumor activity.

Macranthoside A (Kalopanaxsaponin H) is a triterpenoid glycoside extracted from rehmannia and belongs to the iridoterpenoid synthesis. Macranthoside A has anti-inflammatory, antioxidant, antibacterial and neuroprotective activities, inhibits the production of pro-inflammatory cytokines and inhibits the activation of inflammatory signaling pathways, helps neutralize harmful free radicals, protects cells from oxidative damage, and promotes the survival and growth of neurons. And prevent neuronal cell death caused by oxidative stress or neurotoxic compounds, which has the potential to treat neurodegenerative diseases, cardiovascular diseases and liver damage.

20-Hydroxyganoderic acid G is a lanosterane triterpenoid obtained from the ethanolic extract of Ganoderma curtisii (Ganoderma curtisii) cotyledons. 20-Hydroxyganoderic Acid G inhibited LPS-activated BV-2 microglia, with an IC50 value of 21.33 μM. 20-Hydroxyganoderic Acid G was used to study neuroinflammatory diseases associated with LPS activation. 20-Hydroxyganoderic Acid G was used to study neuroinflammatory diseases associated with microglia activated by LPS.

Tubeimoside II (also known as Tubeimoside-B), a natural oleanane-type triterpenoid saponin analogue, exhibits anti-inflammatory, antitumor, and antitumor-promoting properties.

3-Acetyl-11-keto-ursolic acid (Compound 18), a triterpenoid derived from Eriobotrya japonica leaves, exhibits inhibitory activity against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and holds potential for anti-diabetes research [1].

Chromosaponin I (Soyasaponin βg) is a triterpenoid saponin that can be isolated from peas. It has the ability to stimulate root growth in Arabidopsis thaliana seedlings.

Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression

Ganoderic acid Me, a triterpenoid present in Ganoderma lucidum [1], exhibits various biological activities.

Marsglobiferin is a triterpenoid compound that can be isolated from the ethanol extract of calla lily stems.

Brachyoside B, a triterpenoid saponin, is derived from Astragalus wiedemannianus [1].

7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid, a ganoderma triterpenoid found in Ganoderma Lucidum Karst, is acknowledged as a significant bioactive ingredient and can be employed in the investigation of different etiologies.

Ganoderic acid Mk (GA-Mk), a triterpenoid acid derived from Ganoderma lucidum mycelia, exhibits potent anti-proliferative properties and can induce apoptosis in HeLa cells through a mitochondria-mediated pathway, making it significant for cervical cancer research [1] [2].

Cabenoside D (compound 8), a triterpenoid glycoside derived from the methanol extract of lichen root, exhibits anti-inflammatory activity. It effectively inhibits inflammation and the activation of early Epstein-Barr virus antigen (EBV-EA) induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice [1].

Quadranoside III is a triterpenoid compound isolated from the dried stems and leaves of Melissa officinalis with potential antibacterial and antioxidant activities.

Siraitic Acid A is a natural product(cucurbitane triterpenoid) isolated from the root of S. grosvenori .

Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel, specific nucleoside transport inhibitor and exhibits immunosuppressive activity.

Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr

Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway.

Licoricesaponin G2, a pentacyclic triterpenoid derived from Glycyrrhiza aspera, can be used to differentiate crude liquorice from honey-processed liquorice.

Meliadubin B, a natural triterpenoid, effectively inhibits inflammatory responses by suppressing superoxide anion generation in human neutrophils (EC 50 of 5.54 μM) as well as inducible nitric oxide synthase activity. Additionally, it demonstrates significant antifungal properties against the rice pathogen Magnaporthe oryzae, with an IC 50 of 182.50 μM.

18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis.