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CDDO-dhTFEA
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CDDO-dhTFEA
Catalog No. T13604Cas No. 1191265-33-4
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 2 mg | $93 | In Stock | |
| 5 mg | $155 | In Stock | |
| 10 mg | $268 | In Stock | |
| 25 mg | $538 | In Stock | |
| 50 mg | $777 | In Stock | |
| 100 mg | $1,090 | In Stock | |
| 500 mg | $2,170 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD). |
| In vivo | CDDO-dhTFEA restores hypertension, increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis, and inflammation in the chronic kidney disease rats [2]. |
| Molecular Weight | 574.72 |
| Formula | C33H45F3N2O3 |
| Cas No. | 1191265-33-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (174.00 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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