Fluorochemical Library

Catalog No. L5100

Library Compound List Excel SDF

Fluorine atoms have a unique combination of electronic and physical properties. As such, when incorporated into active pharmaceutical ingredients (APIs), fluorine atoms often influence their protein binding affinity and lipophilicity but not the shape of the resulting fluorochemicals. Fluorination can thus significantly impact the bioavailability or metabolic stability of drug substances.

The pivotal role that the element fluorine plays in modulating the properties of bioactive molecules is reflected by the growth of its presence in approved drugs, as evidenced by the fact that between 15% to 20% of all medicines and agrochemicals on the market contain at least one fluorine atom in their structure. As of 2009, the FDA had approved <140 fluorine-containing drugs, such as fluorouracil, Miglitol, Gemcitabine, Sofosbuvir, atorvastatin, fluoxetine, ciprofloxacin, etc.

The judicious introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacokinetic properties.

Nowadays, the application of specialty fluorochemicals in the pharmaceutical industry has been increasingly widespread. TargetMol’s fluorochemical library has become an effective tool for developing new anticancer drugs, anesthetics, antidepressants, antifungals, antiviral drugs, antibiotics, cholesterol lowering agents, and anti-inflammatory agents. In addition, in agricultural uses, the addition of fluorine to many agricultural herbicides, pesticides, and fungicides improves the potency and therefore reduces the required application rate of these substances.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
NMR and HPLC validated to ensure high purity and quality;
All compounds are in stock.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

VEGFR (28)

EGFR (24)

Raf (22)

FLT (19)

c-Kit (18)

5-HT Receptor (18)

DNA/RNA Synthesis (17)

PI3K (17)

Glucocorticoid Receptor (16)

PDGFR (15)

c-Met/HGFR (15)

Bcr-Abl (14)

Dopamine Receptor (14)

Topoisomerase (13)

Src (13)

MEK (12)

Dehydrogenase (12)

p38 MAPK (12)

COX (11)

Potassium Channel (10)

Androgen Receptor (10)

FGFR (9)

JAK (9)

Gamma-secretase (8)

Aurora Kinase (8)

TAM Receptor (7)

Tyrosine Kinases (7)

S6 Kinase (7)

ALK (7)

c-RET (6)

Adrenergic Receptor (6)

GABA Receptor (6)

DNA gyrase (6)

GPR (6)

CDK (6)

GluR (6)

Phospholipase (6)

HDAC (6)

Antifungal (6)

PPAR (5)

HCV Protease (5)

HER (5)

PDE (5)

FAK (5)

Estrogen/progestogen Receptor (5)

HIV Protease (5)

DUB (5)

mTOR (5)

LRRK2 (5)

ERK (5)

Calcium Channel (5)

ATPase (5)

Antibiotic (5)

Syk (5)

Trk receptor (5)

HMG-CoA Reductase (4)

HSP (4)

PARP (4)

Beta Amyloid (4)

CFTR (4)

BTK (4)

DPP-4 (4)

IκB/IKK (4)

Sodium Channel (4)

NMDAR (4)

PLK (4)

CCR (4)

Caspase (4)

Antibacterial (4)

Epigenetic Reader Domain (4)

Cysteine Protease (4)

DprE1 (3)

P2 Receptor (3)

IGF-1R (3)

IDO (3)

AChR (3)

Hydroxylase (3)

transporter (3)

Liver X Receptor (3)

MAO (3)

Tie-2 (3)

Antifection (3)

PYK2 (3)

BACE (3)

Serine Protease (3)

CETP (3)

Proton pump (3)

CSF-1R (3)

CRM1 (3)

Pim (3)

GSK-3 (3)

GRK (3)

PKA (3)

Protease-activated Receptor (3)

FXR (3)

NAMPT (2)

Monocarboxylate transporter (2)

MRP (2)

Neurokinin receptor (2)

Reductase (2)

TNF (2)

OX Receptor (2)

P450 (2)

PERK (2)

STAT (2)

SGLT (2)

S1P Receptor (2)

ROS (2)

TRP/TRPV Channel (2)

ROCK (2)

Mdm2 (2)

IAP (2)

MAPK (2)

Autophagy (2)

DNA-PK (2)

Discoidin Domain Receptor (DDR) (2)

Chloride channel (2)

Hedgehog/Smoothened (2)

HIF (2)

Histamine Receptor (2)

Casein Kinase (2)

FAAH (2)

IL Receptor (2)

Carbonic Anhydrase (2)

ATM/ATR (2)

Annexin A (2)

Lipase (2)

Adenosine Receptor (2)

Akt (2)

Ephrin Receptor (2)

Transferase (1)

UGT (1)

E1/E2/E3 Enzyme (1)

TGF-beta/Smad (1)

Reverse Transcriptase (1)

Rho (1)

DNA Alkylation (1)

Wnk (1)

c-Myc (1)

ACK (1)

Chk (1)

Cannabinoid Receptor (1)

BCL (1)

Serine/threonin kinase (1)

ASK (1)

Serotonin Transporter (1)

CaSR (1)

Sigma receptor (1)

Sirtuin (1)

Bombesin Receptor (1)

AhR (1)

GluCls (1)

FOXO1 (1)

Neuropeptide Y Receptor (1)

Influenza Virus (1)

Nrf2 (1)

NPC1L1 (1)

NOS (1)

NOD (1)

Integrase (1)

Integrin (1)

Histone Methyltransferase (1)

JNK (1)

Kinesin (1)

MTH1 (1)

LHRH (1)

LIM Kinase (1)

Monoamine Transporter (1)

Immunology & Inflammation related (1)

Histone Acetyltransferase (1)

Prostaglandin Receptor (1)

HBV (1)

Glucagon Receptor (1)

lysosomal autophagy (1)

Glucokinase (1)

GNRH Receptor (1)

GTPase (1)

Guanylate cyclase (1)

Phosphatase (1)

p53 (1)

PGE Synthase (1)

PDK (1)

HIF/HIF Prolyl-Hydroxylase (1)

Parasite (1)

PAK (1)

PAI-1 (1)

Wnt/beta-catenin (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty