Home Tools
Log in
Cart

Fluorochemical Library

Catalog No. L5100
  Library Compound List   Excel SDF

Fluorine atoms have a unique combination of electronic and physical properties. As such, when incorporated into active pharmaceutical ingredients (APIs), fluorine atoms often influence their protein binding affinity and lipophilicity but not the shape of the resulting fluorochemicals. Fluorination can thus significantly impact the bioavailability or metabolic stability of drug substances.

The pivotal role that the element fluorine plays in modulating the properties of bioactive molecules is reflected by the growth of its presence in approved drugs, as evidenced by the fact that between 15% to 20% of all medicines and agrochemicals on the market contain at least one fluorine atom in their structure. As of 2009, the FDA had approved >140 fluorine-containing drugs, such as fluorouracil, Miglitol, Gemcitabine, Sofosbuvir, atorvastatin, fluoxetine, ciprofloxacin, etc.

The judicious introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacokinetic properties.

Nowadays, the application of specialty fluorochemicals in the pharmaceutical industry has been increasingly widespread. TargetMol’s fluorochemical library has become an effective tool for developing new anticancer drugs, anesthetics, antidepressants, antifungals, antiviral drugs, antibiotics, cholesterol lowering agents, and anti-inflammatory agents. In addition, in agricultural uses, the addition of fluorine to many agricultural herbicides, pesticides, and fungicides improves the potency and therefore reduces the required application rate of these substances.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Please contact us for prices and availability for the specification of product you are interested at.
Get quote
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
Get quote

Product Description

  • A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality;
  • All compounds are in stock.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L5100)

Library Composition

VEGFR (28)
EGFR (24)
Raf (22)
FLT (19)
c-Kit (18)
5-HT Receptor (18)
DNA/RNA Synthesis (17)
PI3K (17)
Glucocorticoid Receptor (16)
PDGFR (15)
c-Met/HGFR (15)
Bcr-Abl (14)
Dopamine Receptor (14)
Topoisomerase (13)
Src (13)
MEK (12)
Dehydrogenase (12)
p38 MAPK (12)
COX (11)
Potassium Channel (10)
Androgen Receptor (10)
FGFR (9)
JAK (9)
Gamma-secretase (8)
Aurora Kinase (8)
TAM Receptor (7)
Tyrosine Kinases (7)
S6 Kinase (7)
ALK (7)
c-RET (6)
Adrenergic Receptor (6)
GABA Receptor (6)
DNA gyrase (6)
GPR (6)
CDK (6)
GluR (6)
Phospholipase (6)
HDAC (6)
Antifungal (6)
PPAR (5)
HCV Protease (5)
HER (5)
PDE (5)
FAK (5)
Estrogen/progestogen Receptor (5)
HIV Protease (5)
DUB (5)
mTOR (5)
LRRK2 (5)
ERK (5)
Calcium Channel (5)
ATPase (5)
Antibiotic (5)
Syk (5)
Trk receptor (5)
HMG-CoA Reductase (4)
HSP (4)
PARP (4)
Beta Amyloid (4)
CFTR (4)
BTK (4)
DPP-4 (4)
IκB/IKK (4)
Sodium Channel (4)
NMDAR (4)
PLK (4)
CCR (4)
Caspase (4)
Antibacterial (4)
Epigenetic Reader Domain (4)
Cysteine Protease (4)
DprE1 (3)
P2 Receptor (3)
IGF-1R (3)
IDO (3)
AChR (3)
Hydroxylase (3)
transporter (3)
Liver X Receptor (3)
MAO (3)
Tie-2 (3)
Antifection (3)
PYK2 (3)
BACE (3)
Serine Protease (3)
CETP (3)
Proton pump (3)
CSF-1R (3)
CRM1 (3)
Pim (3)
GSK-3 (3)
GRK (3)
PKA (3)
Protease-activated Receptor (3)
FXR (3)
NAMPT (2)
Monocarboxylate transporter (2)
MRP (2)
Neurokinin receptor (2)
Reductase (2)
TNF (2)
OX Receptor (2)
P450 (2)
PERK (2)
STAT (2)
SGLT (2)
S1P Receptor (2)
ROS (2)
TRP/TRPV Channel (2)
ROCK (2)
Mdm2 (2)
IAP (2)
MAPK (2)
Autophagy (2)
DNA-PK (2)
Discoidin Domain Receptor (DDR) (2)
Chloride channel (2)
Hedgehog/Smoothened (2)
HIF (2)
Histamine Receptor (2)
Casein Kinase (2)
FAAH (2)
IL Receptor (2)
Carbonic Anhydrase (2)
ATM/ATR (2)
Annexin A (2)
Lipase (2)
Adenosine Receptor (2)
Akt (2)
Ephrin Receptor (2)
Transferase (1)
UGT (1)
E1/E2/E3 Enzyme (1)
TGF-beta/Smad (1)
Reverse Transcriptase (1)
Rho (1)
DNA Alkylation (1)
Wnk (1)
c-Myc (1)
ACK (1)
Chk (1)
Cannabinoid Receptor (1)
BCL (1)
Serine/threonin kinase (1)
ASK (1)
Serotonin Transporter (1)
CaSR (1)
Sigma receptor (1)
Sirtuin (1)
Bombesin Receptor (1)
AhR (1)
GluCls (1)
FOXO1 (1)
Neuropeptide Y Receptor (1)
Influenza Virus (1)
Nrf2 (1)
NPC1L1 (1)
NOS (1)
NOD (1)
Integrase (1)
Integrin (1)
Histone Methyltransferase (1)
JNK (1)
Kinesin (1)
MTH1 (1)
LHRH (1)
LIM Kinase (1)
Monoamine Transporter (1)
Immunology & Inflammation related (1)
Histone Acetyltransferase (1)
Prostaglandin Receptor (1)
HBV (1)
Glucagon Receptor (1)
lysosomal autophagy (1)
Glucokinase (1)
GNRH Receptor (1)
GTPase (1)
Guanylate cyclase (1)
Phosphatase (1)
p53 (1)
PGE Synthase (1)
PDK (1)
HIF/HIF Prolyl-Hydroxylase (1)
Parasite (1)
PAK (1)
PAI-1 (1)
Wnt/beta-catenin (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE