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26-Deoxyactein

🥰Excellent
Catalog No. TN1222Cas No. 264624-38-6
Alias 27-Deoxyactein

23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.

26-Deoxyactein

26-Deoxyactein

🥰Excellent
Purity: 98.06%
Catalog No. TN1222Alias 27-DeoxyacteinCas No. 264624-38-6
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.
Pack SizePriceAvailabilityQuantity
1 mg$98In Stock
5 mg$263In Stock
10 mg$388In Stock
25 mg$639In Stock
1 mL x 10 mM (in DMSO)$349In Stock
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Purity:98.06%
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Product Introduction

Bioactivity
Description
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.
In vitro
Black cohosh rhizomes were extracted with methanol/water and fractionated by solvent-solvent partitioning to yield three fractions: hexane, ethyl acetate and water. The ethyl acetate fraction displayed the highest potency in two cell-based assays, growth inhibition and cell cycle analysis. This fraction inhibited growth of both the ER+ MCF7 and ER-MDA-MB-453 human breast cancer cell lines with IC50 values of about 20 and 10 micro g/ml, respectively. It also induced cell cycle arrest at G1 when tested at 30 micro g/ml and at G2/M at 60 micro g/ml in MCF7 cells. This suggests that the extract contains a mixture of components with the more active (or more abundant) causing G1 arrest and the less active causing G2/M arrest. We then examined specific components in this extract. The triterpene glycoside fraction obtained by polyamide column chromatography, and the specific triterpene glycosides actein, 23-epi-26-Deoxyactein and cimiracemoside A, inhibited growth of the MCF7 human breast cancer cells and induced cell cycle arrest at G1[1]
Alias27-Deoxyactein
Chemical Properties
Molecular Weight660.83
FormulaC37H56O10
Cas No.264624-38-6
Smiles[H][C@@]12O[C@]1(C)CO[C@]21C[C@@H](C)[C@@]2([H])[C@]([H])(C[C@@]3(C)[C@]4([H])CC[C@]5([H])[C@]6(C[C@@]46C[C@@H](OC(C)=O)[C@]23C)CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C5(C)C)O1
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 70 mg/mL (105.93 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5132 mL7.5662 mL15.1325 mL75.6624 mL
5 mM0.3026 mL1.5132 mL3.0265 mL15.1325 mL
10 mM0.1513 mL0.7566 mL1.5132 mL7.5662 mL
20 mM0.0757 mL0.3783 mL0.7566 mL3.7831 mL
50 mM0.0303 mL0.1513 mL0.3026 mL1.5132 mL
100 mM0.0151 mL0.0757 mL0.1513 mL0.7566 mL

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