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Tau-aggregation and neuroinflammation-IN-1
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Purity:100%
Tau-aggregation and neuroinflammation-IN-1
Catalog No. T62899Cas No. 2175953-98-5
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. It has anti-inflammatory activity, reduces NO release, exhibits low cytotoxicity against LSP-stimulated BV2 cells, and reverses okadaic acid-induced memory impairment in rats.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $122 | In Stock | |
| 50 mg | $197 | In Stock | |
| 100 mg | $293 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. It has anti-inflammatory activity, reduces NO release, exhibits low cytotoxicity against LSP-stimulated BV2 cells, and reverses okadaic acid-induced memory impairment in rats. |
| In vitro | Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM and exhibits no significant hepatotoxicity at high concentrations in LO2 cells, without affecting the viability of BV2 cells at 20 μM. Tau-aggregation and neuroinflammation-IN-1 (2.5, 5, and 10 μM; 24 h) maintain the anti-inflammatory effect of sodium usage and decrease the NO release rate by 41% at 10 μM in LPS-stimulated BV2 cells.[1] |
| In vivo | Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; I.P.; for 7 days, followed by 7 additional days post-OA injection; Male SD rats) significantly enhances spatial memory and cognitive abilities in OA-induced rats.[1] |
| Molecular Weight | 460.44 |
| Formula | C25H20N2O7 |
| Cas No. | 2175953-98-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (108.59 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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