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8A8
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Catalog No. T73580Cas No. 2766594-12-9
8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferation in HaCat cells [1].
8A8
😃Good
Catalog No. T73580Cas No. 2766594-12-9
8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferation in HaCat cells [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferation in HaCat cells [1]. |
| In vitro | Compound 8A8, at a low concentration (2.5 μM; RAW 264.7 cells), markedly reduced IL-6 and TNF-α levels, achieving half the concentration of these cytokines compared to post-LPS treatment at 5 μM. Furthermore, the levels of IL-6 and TNF-α in cell supernatants were reduced to a quarter following treatment with a high concentration of compound 8A8 (10 μM) [1]. |
| Molecular Weight | 799.06 |
| Formula | C36H37BrClN5O9 |
| Cas No. | 2766594-12-9 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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