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Zagociguat
🥰Excellent
Catalog No. T39673Cas No. 2201048-82-8
Alias IW-6463, IW6463, CY-6463, CY6463
Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.
Zagociguat
🥰Excellent
Catalog No. T39673Alias IW-6463, IW6463, CY-6463, CY6463Cas No. 2201048-82-8
Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $100 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $787 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,650 | In Stock | |
| 200 mg | $2,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $272 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zagociguat (CY6463) is a soluble guanylate cyclase stimulator with central nervous system penetrance, enhancing nitric oxide (NO) signaling and used in the study of neurological diseases. |
| Targets&IC50 | CREB:25.7 nM (EC50) |
| In vitro | CREB phosphorylation was stimulated by Zagociguat in a concentration-dependent manner in primary rat neurons with EC50 of 25.7 nM. [1] |
| In vivo | When Zagociguat was administered to rats at 10 mg/kg, cGMP levels were higher in cerebrospinal fluid compared to 3 mg/kg, suggesting that Zagociguat is a CNS permeable compound capable of triggering an increase in cGMP in the CNS. Zagociguat (10 mg/kg) decreased plasma inflammatory markers and increased BDNF in obese mice. [1] |
| Alias | IW-6463, IW6463, CY-6463, CY6463 |
| Molecular Weight | 362.28 |
| Formula | C16H10F4N6 |
| Cas No. | 2201048-82-8 |
| Smiles | FC=1C=CC=CC1CC2=NC(=CN3C=CN=C23)C4=NN=C(N4)C(F)(F)F |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200.00 mg/mL (552.06 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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