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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $115 | In Stock | |
5 mg | $280 | In Stock | |
10 mg | $415 | In Stock | |
25 mg | $689 | In Stock | |
50 mg | $983 | In Stock | |
1 mL x 10 mM (in DMSO) | $290 | In Stock |
Description | Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. |
In vitro | The effect of CMG neutral extract (25-200 microg/ml) and Tirucallol (0.1-100 microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65. |
Molecular Weight | 426.72 |
Formula | C30H50O |
Cas No. | 514-46-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 4.27 mg/mL (10 mM), Sonication is recommended. ![]() | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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