csf1r

Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.

CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.

(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide is a cannabinoid receptor antagonist/inverse agonist.

CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).

CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).

CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF1R-IN-5 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-5 has the potential to be used in the study of cancer diseases.

CSF1R-IN-4 is a potent inhibitor of CSF-1R. CSF1R-IN-4 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-4 has potential for the study of cancer diseases. EGFR-IN-40.

CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF1R-IN-6 is a potent inhibitor of CSF1R, which is expressed in macrophages and is dependent on the CSF-1/CSF-1R signalling pathway for survival and differentiation of macrophages. Compound 5).

CSF1R-IN-14, an isoindolinone derivative compound, is a potent inhibitor of CSF1R. CSF1R-IN-14 has potential for cancer disease research.

CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1].

CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing effects by inhibiting the migration of macrophages and inducing the reprogramming of M2-type macrophages to M1-type macrophages, thus exhibited activity against colorectal cancer cells.

CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.

CSF1R-IN-7 (Formula I) is a CSF-1R inhibitor that can be used to study Alzheimer's disease.

CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).

CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM. It is capable of inhibiting osteoclast differentiation [1].

CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).

Saniculoside R 1 is a new triterpenoid saponin from Sanicula europaea.

(R)-1-Amino-3-chloro-2-propanol hydrochloride is a biochemical.

OT-R antagonist 1 inhibits oxytocin-evoked intracellular Ca2+ mobilization (IC50 = 8 nM). OT-R antagonist 1 is a new effective and selective nonpeptide low molecular weight OT-R antagonist.

(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNA, with inhibition concentration (IC50) values of 3.1 μM and 5.5 μM, respectively [1].

Anti-MI/R injury agent 1 (compound 18), derived from Panaxatriol, represents an orally administered, potent agent against myocardial ischemia/reperfusion (MI/R) injury. It improves cell viability in cardiomyocytes subjected to oxygen-glucose deprivation and reperfusion (OGD/R)-induced injury. Furthermore, this compound significantly reduces myocardial infarction size, diminishes levels of circulating cardiac troponin I (cTnI), and mitigates cardiac tissue damage in rat models [1].

(R)-1-PeCSO, also known as trans-(+)-S-1-Propenyl-L-cysteine sulfoxide, constitutes the primary flavor precursor in onions [1].

(R)-Necrocide 1 (compound (R)-38) is a potent anticancer agent with antiproliferative activity [1].

(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].

(R)-3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-ol is a useful organic compound for research related to life sciences. The catalog number is T66410 and the CAS number is 132335-49-0.

(R)-2,5-Ddioxopyrrolidin-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate is a useful organic compound for research related to life sciences. The catalog number is T66773 and the CAS number is 3674-18-8.

Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is a useful organic compound for research related to life sciences. The catalog number is T67229 and the CAS number is 379270-35-6.

(R)-2-Amino-3-cyclohexylpropanoic acid hydrate(1:x) is a useful organic compound for research related to life sciences. The catalog number is T66758 and the CAS number is 213178-94-0.

(R)-2-(1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T65185 and the CAS number is 193693-61-7.

Phosphonomycin (R)-1-phenethylamine salt is a useful organic compound for research related to life sciences. The catalog number is T65395 and the CAS number is 25383-07-7.

(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T65597.

(R)-tert-Butyl (1-benzylpiperidin-3-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66733 and the CAS number is 454713-13-4.

(S)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67269.

(R)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67274.

1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 μM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 μM) reduces lipid peroxidation induced byFXNsiRNA knockdown in NBT human myoblasts. 1.Cotticelli, M.G., Forestieri, R., Xia, S., et al.Identification of a novel oleic acid analog with protective effects in multiple cellular models of Friedreich ataxiaACS Chem. Neurosci.11(17)2535-2542(2020)

(R)-2-Amino-2-(cyclohexa-1,4-dien-1-yl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T64929 and the CAS number is 26774-88-9.

(R)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64535.

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66629 and the CAS number is 247068-82-2.

(R)-TTBK1-IN-1 is a potent, selective, and brain-penetrant inhibitor of tau tubulin kinase 1 (TTBK1), serving as an enantiomer of TTBK1-IN-1. It finds application in the research of Alzheimer’s disease and related tauopathies [1].

(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one is a natural product for research related to life sciences. The catalog number is TN6384 and the CAS number is 1961196-24-6.

(R)-1-Benzylpyrrolidine-2-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65422 and the CAS number is 56080-99-0.

(R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is a useful organic compound for research related to life sciences. The catalog number is T66279 and the CAS number is 877399-00-3.

(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol is a useful organic compound for research related to life sciences. The catalog number is T66409 and the CAS number is 116539-57-2.

somatostatin sst2 receptor agonist

(R)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T66465.

(R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetic acid is a useful organic compound for research related to life sciences. The catalog number is T65534 and the CAS number is 63422-71-9.

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate is a useful organic compound for research related to life sciences. The catalog number is T65075 and the CAS number is 17110-51-9.

GnRH-R antagonist 1 (Compound 21a), is an orally active, membrane-permeable agent with a high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic efficacy (IC50=2.18 nM). It is utilized in research focused on advanced prostate cancer and the prevention of premature LH surges [1].

(R)-1-[(R)-tert-Butylphosphinoyl]-2-[(R)-1-(diphenylphosphino)ethyl]ferrocene is a useful organic compound for research related to life sciences and the catalog number is T67234.

(R)-1-(2-Naphthyl)ethylamine is a useful organic compound for research related to life sciences. The catalog number is T67004 and the CAS number is 3906-16-9.