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Ki20227

🥰Excellent
Catalog No. T4315Cas No. 623142-96-1

Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.

Ki20227

Ki20227

🥰Excellent
Purity: 99.37%
Catalog No. T4315Cas No. 623142-96-1
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$97In Stock
10 mg$156In Stock
25 mg$297In Stock
50 mg$488In Stock
100 mg$778In Stock
200 mg$1,060In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Purity:99.37%
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Product Introduction

Bioactivity
Description
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.
Targets&IC50
CSF1R:2 nM, VEGFR2:12 nM
In vitro
Ki20227 hasn't inhibition for other kinases tested, such as EGFR, Fms-like tyrosine kinase-3, or c-Src (c-src proto-oncogene product). Ki20227 also inhibits the M-CSF-dependent growth of M-NFS-60 cells but not the M-CSF-independent growth of A375 human melanoma cells in vitro. Ki20227 has an inhibition against M-CSF-dependent reactions, such as lipopolysaccharide-induced TNF-α production, which was enhanced by M-CSF in vitro.
In vivo
Ki20227 reduces the number of tartrate-resistant acid phosphatase-positive osteoclast-like cells on bone surfaces in ovariectomized (ovx) rats. Furthermore, in the Ki20227-treated mice, the number of CD11b(+), Gr-1(+), and Ly-6 g(+) cells in the spleen were decreased and the CII-induced cytokine production in splenocytes isolated from the Ki20227-treated arthritic mice was also reduced. In EAE animal model, Ki20227 inhibits the turn-over/expansion of myeloid cells provoked by the immunization and subsequent MOG-specific T cell responses.
Chemical Properties
Molecular Weight480.54
FormulaC24H24N4O5S
Cas No.623142-96-1
SmilesCOc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1
Relative Density.1.327 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (114.45 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0810 mL10.4050 mL20.8099 mL104.0496 mL
5 mM0.4162 mL2.0810 mL4.1620 mL20.8099 mL
10 mM0.2081 mL1.0405 mL2.0810 mL10.4050 mL
20 mM0.1040 mL0.5202 mL1.0405 mL5.2025 mL
50 mM0.0416 mL0.2081 mL0.4162 mL2.0810 mL
100 mM0.0208 mL0.1040 mL0.2081 mL1.0405 mL

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