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GENZ-882706
Catalog No. T11390Cas No. 2070864-35-4
Alias RA03546849
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor.
GENZ-882706
Catalog No. T11390Alias RA03546849Cas No. 2070864-35-4
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,130 | 10-14 weeks | |
| 50 mg | $2,770 | 10-14 weeks | |
| 100 mg | $4,470 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor. |
| In vitro | Genz-882706 enhances proliferative activity in unstimulated cells 48 hours post-treatment. |
| In vivo | Daily administration of Genz-882706 markedly attenuates experimental autoimmune encephalomyelitis (EAE) severity. In EAE-affected mice, Genz-882706 significantly lowers MCP-1, IL-6, IL-1β, and IP-10 levels in spinal cord homogenates, contrasting sharply with those treated with a vehicle. Conversely, TNF-α levels in the spinal cord notably increase following Genz-882706 treatment compared to the vehicle group. Furthermore, Genz-882706 administrations, at both 30 mg/kg and 100 mg/kg dosages, substantially decrease the population of microglia and monocytes/macrophages in the brain and spinal cord, standing out from vehicle and LPS controls. Additionally, Genz-882706 modestly diminishes CD80 expression on monocytes/macrophages within the brain. |
| Alias | RA03546849 |
| Molecular Weight | 455.51 |
| Formula | C26H25N5O3 |
| Cas No. | 2070864-35-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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