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CHMFL-ABL/KIT-155
Catalog No. T10801Cas No. 2081093-21-0
Alias CHMFL-ABL-KIT-155
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.
CHMFL-ABL/KIT-155
Catalog No. T10801Alias CHMFL-ABL-KIT-155Cas No. 2081093-21-0
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 6-8 weeks | |
| 50 mg | $2,180 | 6-8 weeks | |
| 100 mg | $2,800 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis. |
| Targets&IC50 | Lck:12 nM , Abl (type II):46 nM , CSF1R:227 nM , DDR2:325 nM , DDR1:116 nM , BLK:81 nM , PDGFRβ:80 nM , c-Kit:75 nM |
| In vitro | CHMFL-ABL/KIT-155 also presents significant inhibitory activities to BLK, CSF1R, DDR1, DDR2, LCK and PDGFRβ (IC50s: 81 nM, 227 nM, 116 nM, 325 nM,12 nM, and 80 nM) kinases. CHMFL-ABL/KIT-155 exhibits anti-proliferation activities in the BCR-ABL dependent CML cancer cell lines such as MEG-01 (GI50: 0.02 μM), K562 (GI50: 0.027 μM), and KU812 (GI50: 0.056 μM). It also potently inhibits the growth of c-KIT dependent GISTs cancer cell lines including GIST-882 (GI50: 0.095 μM), GIST-T1 (GI50: 0.023 μM) but not c-KIT independent GIST-48B (GI50: 3.96 μM). |
| In vivo | In female nu/nu mice bearing established K562 tumor xenografts, CHMFL-ABL/KIT-155 (25-100 mg/kg; p.o.; once daily for 28 days) shows dose-dependent tumor progression suppression without apparent toxicity. |
| Alias | CHMFL-ABL-KIT-155 |
| Molecular Weight | 609.68 |
| Formula | C33H38F3N5O3 |
| Cas No. | 2081093-21-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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