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CSF1R-IN-3

🥰Excellent
Catalog No. T64066Cas No. 2760584-90-3

CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing effects by inhibiting the migration of macrophages and inducing the reprogramming of M2-type macrophages to M1-type macrophages, thus exhibited activity against colorectal cancer cells.

CSF1R-IN-3

CSF1R-IN-3

🥰Excellent
Purity: 97.31%
Catalog No. T64066Cas No. 2760584-90-3
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing effects by inhibiting the migration of macrophages and inducing the reprogramming of M2-type macrophages to M1-type macrophages, thus exhibited activity against colorectal cancer cells.
Pack SizePriceAvailabilityQuantity
1 mg$108In Stock
5 mg$272In Stock
10 mg$397In Stock
25 mg$738In Stock
50 mg$1,080In Stock
100 mg$1,550In Stock
1 mL x 10 mM (in DMSO)$343In Stock
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Purity:97.31%
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Product Introduction

Bioactivity
Description
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing effects by inhibiting the migration of macrophages and inducing the reprogramming of M2-type macrophages to M1-type macrophages, thus exhibited activity against colorectal cancer cells.
Targets&IC50
CSF1R:2.1 nM
Chemical Properties
Molecular Weight574.67
FormulaC30H38N8O4
Cas No.2760584-90-3
SmilesCN1CCN(CC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4cc(NC(=O)Nc5cc(on5)C(C)(C)C)ccc34)c2C)CC1
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 56.2 mg/mL (97.9 mM ), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7401 mL8.7006 mL17.4013 mL87.0065 mL
5 mM0.3480 mL1.7401 mL3.4803 mL17.4013 mL
10 mM0.1740 mL0.8701 mL1.7401 mL8.7006 mL
20 mM0.0870 mL0.4350 mL0.8701 mL4.3503 mL
50 mM0.0348 mL0.1740 mL0.3480 mL1.7401 mL

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