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CSF1R-IN-2

CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).

Catalog No. T13194Cas No. 2271119-26-5

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Purity:99.29%

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COA HNMR HPLC LCMS

CSF1R-IN-2

Catalog No. T13194Cas No. 2271119-26-5

CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$64	In Stock
2 mg	$93	In Stock
5 mg	$155	In Stock
10 mg	$222	In Stock
25 mg	$413	In Stock
50 mg	$618	In Stock
100 mg	$879	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock

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Product Introduction

Bioactivity

Description	CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
Targets&IC50	MET:0.14 nM , c-Fms:0.76 nM , Src:0.12 nM
In vitro	The suppression of MET autophosphorylation as well as the downstream STAT3 caused by CSF1R-IN-2, ERK and AKT phosphorylation at IC50 values of around 1-3 nM in SNU-5 and MKN-45 cell lines.
In vivo	In mice, CSF1R-IN-2 (p.o., BID, 13 days) treatment results in an 85% tumor regression, and no bodyweight loss is observed after 21 days of treatment. In SCID/Beige mice. CSF1R-IN-2 (p.o., BID, 10 days) demonstrates the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID, and 15 mg/kg, BID, respectively. In mice, CSF1R-IN-2 inhibits MET activity in MKN-45 tumors following oral administration.

Chemical Properties

Molecular Weight	409.42
Formula	C₂₀H₂₀FN₇O₂
Cas No.	2271119-26-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 25 mg/mL (61.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4425 mL	12.2124 mL	24.4248 mL	122.1240 mL
5 mM	0.4885 mL	2.4425 mL	4.8850 mL	24.4248 mL
10 mM	0.2442 mL	1.2212 mL	2.4425 mL	12.2124 mL
20 mM	0.1221 mL	0.6106 mL	1.2212 mL	6.1062 mL
50 mM	0.0488 mL	0.2442 mL	0.4885 mL	2.4425 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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