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CSF1R-IN-1

CSF1R-IN-1 is a CSF1R inhibitor with an IC50 of 0.5 nM.

Catalog No. T10894Cas No. 2095849-04-8

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Purity:98.56%

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COA HNMR HPLC

CSF1R-IN-1

Catalog No. T10894Cas No. 2095849-04-8

CSF1R-IN-1 is a CSF1R inhibitor with an IC50 of 0.5 nM.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$63	In Stock
5 mg	$133	In Stock
10 mg	$198	In Stock
25 mg	$347	In Stock
50 mg	$497	In Stock
100 mg	$690	In Stock
200 mg	$926	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock

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Product Introduction

Bioactivity

Description	CSF1R-IN-1 is a CSF1R inhibitor with an IC50 of 0.5 nM.
Targets&IC50	CSF1R:0.5 nM
In vitro	It is believed that CSF1R plays an important role in the recruitment and differentiation of tumor-associated macrophages (TAM). CSF1R-IN-1 showed good intestinal permeability in Caco2 analysis.
In vivo	CSF1R-IN-1 has good pharmacokinetics when administered orally to mice. It seems suitable for in vivo pharmacological testing in an appropriate preclinical tumor model to prove a proof of concept.

Chemical Properties

Molecular Weight	479.45
Formula	C₂₅H₂₀F₃N₅O₂
Cas No.	2095849-04-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 83.33 mg/mL (173.80 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0857 mL	10.4286 mL	20.8572 mL	104.2862 mL
5 mM	0.4171 mL	2.0857 mL	4.1714 mL	20.8572 mL
10 mM	0.2086 mL	1.0429 mL	2.0857 mL	10.4286 mL
20 mM	0.1043 mL	0.5214 mL	1.0429 mL	5.2143 mL
50 mM	0.0417 mL	0.2086 mL	0.4171 mL	2.0857 mL
100 mM	0.0209 mL	0.1043 mL	0.2086 mL	1.0429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc