Diflapolin

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH) inhibitor, exhibiting marked anti-inflammatory efficacy and high target selectivity.

Catalog No. T8844Cas No. 724453-98-9

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Purity:99.23%

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COA HPLC HNMR

Diflapolin

Catalog No. T8844Cas No. 724453-98-9

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH) inhibitor, exhibiting marked anti-inflammatory efficacy and high target selectivity.

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Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$67	In Stock
25 mg	$145	In Stock
50 mg	$243	In Stock
100 mg	$354	In Stock
500 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$38	In Stock

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Product Introduction

Bioactivity

Description	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH) inhibitor, exhibiting marked anti-inflammatory efficacy and high target selectivity.
Targets&IC50	Others:20 nM, FLAP:20 nM
In vitro	Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM).
In vivo	Diflapolin (1-10 mg/kg; i.p.; 30 min before zymosan injection) demonstrates potent anti-inflammatory properties in in-vivo experiments.

Chemical Properties

Molecular Weight	458.36
Formula	C₂₂H₁₇Cl₂N₃O₂S
Cas No.	724453-98-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 84 mg/mL (183.26 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1817 mL	10.9085 mL	21.8169 mL	109.0846 mL
5 mM	0.4363 mL	2.1817 mL	4.3634 mL	21.8169 mL
10 mM	0.2182 mL	1.0908 mL	2.1817 mL	10.9085 mL
20 mM	0.1091 mL	0.5454 mL	1.0908 mL	5.4542 mL
50 mM	0.0436 mL	0.2182 mL	0.4363 mL	2.1817 mL
100 mM	0.0218 mL	0.1091 mL	0.2182 mL	1.0908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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