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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $39 | In Stock | |
25 mg | $79 | In Stock | |
50 mg | $131 | In Stock | |
100 mg | $211 | In Stock | |
200 mg | $313 | In Stock |
Description | CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases. |
Targets&IC50 | sEH (human):112 nM, sEH (mouse):11.1 nM |
In vitro | CUDA (10 μM; 18 hours) induced a 6-fold and 3-fold increase in PPARalpha mRNA expression in COS-7 cells without altering PPARalpha protein levels. It competitively inhibits Wy-14643 (pirinixic acid) binding to the PPARalpha ligand binding domain, indicating its role as a PPARalpha ligand. |
Molecular Weight | 340.5 |
Formula | C19H36N2O3 |
Cas No. | 479413-68-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 3.41 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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