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GSK2256294A
🥰Excellent
Catalog No. T15430Cas No. 1142090-23-0
Alias GSK 2256294
GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.
GSK2256294A
🥰Excellent
Purity: 99.27%
Catalog No. T15430Alias GSK 2256294Cas No. 1142090-23-0
GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 2 mg | $136 | In Stock | |
| 5 mg | $217 | In Stock | |
| 10 mg | $347 | In Stock | |
| 25 mg | $525 | In Stock | |
| 50 mg | $695 | In Stock | |
| 100 mg | $919 | In Stock |
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Purity:99.27%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively. |
| Targets&IC50 | sEH:189 pM (mouse), sEH:27 pM (human), sEH:61 pM (rat) |
| In vitro | GSK2256294A displays potent cellular inhibition of sEH with an IC50 of 0.66 nM in an assay developed using a cell line transfected with the human sEH enzyme[1]. |
| In vivo | Mice receiving 10 days of cigarette smoke exposure concomitant with oral administration of GSK2256294A exhibits significant, dose-dependent reductions in pulmonary leukocytes and keratinocyte chemoattractant levels. Mice receiving oral administration of G |
| Alias | GSK 2256294 |
| Molecular Weight | 447.46 |
| Formula | C21H24F3N7O |
| Cas No. | 1142090-23-0 |
| Smiles | CNc1nc(C)nc(N[C@H]2CCC[C@H](C2)C(=O)NCc2ccc(cc2C(F)(F)F)C#N)n1 |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.48 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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