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VU534
🥰Excellent
Catalog No. T77594Cas No. 923509-20-0
VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related to cardiometabolism.
VU534
🥰Excellent
Purity: 99.22%
Catalog No. T77594Cas No. 923509-20-0
VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related to cardiometabolism.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $84 | In Stock | |
| 10 mg | $139 | In Stock | |
| 25 mg | $235 | In Stock | |
| 50 mg | $353 | In Stock | |
| 100 mg | $533 | In Stock |
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Purity:99.22%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related to cardiometabolism. |
| Targets&IC50 | FAAH:1.2 μM, NAPE-PLD:0.30 μM(EC50), sEH:1.2 μM |
| In vitro | VU534 (30 μM; 24 h) is less cytotoxic to HepG2 and Raw264.7 cell lines.[1] VU534 (3~30 μM; 1 h) can increase NAPE-PLD activity in Raw264.7 cells.[1] VU534 (1 h) can increase NAPE-PLD activity in HepG2 cells with an EC50 value of 1.5 μM.[1] VU534 (5 μM, 1 h) increased NAPE-PLD activity 1.5-fold but did not reverse NAPE-PLD activity inhibited by LEI–401.[1] VU534 (10 μM; 6 h) significantly enhances efferocytosis of bone marrow-derived macrophages but cannot exert this effect when Napepld is knocked out.[1] |
| Molecular Weight | 447.55 |
| Formula | C21H22FN3O3S2 |
| Cas No. | 923509-20-0 |
| Smiles | CC1=CC2=C(SC(NC(=O)C3CCN(CC3)S(=O)(=O)C3=CC=C(F)C=C3)=N2)C(C)=C1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
| Solubility Information | DMSO: ＜1 mg/mL (insoluble or slightly soluble), Sonication is recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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