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Lansoprazole
Catalog No. T0674Cas No. 103577-45-3
Alias AG-1749, A-65006
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
Lansoprazole
Catalog No. T0674Alias AG-1749, A-65006Cas No. 103577-45-3
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $45 | In Stock | |
| 1 g | $62 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) |
| In vitro | Lansoprazole significantly attenuates intestinal damage induced by ischemia-reperfusion or indomethacin. Exogenous administration of Lansoprazole can prevent injury to the small intestine caused by ischemia-reperfusion or indomethacin. Lansoprazole inhibits acute inflammatory responses and mucosal injury in rats subjected to ischemia-reperfusion or indomethacin-induced damage. |
| In vivo | Lansoprazole is a potent antisecretory agent that inhibits gastric acid secretion by blocking the stomach's hydrogen/potassium adenosine triphosphatase (H+, K+-ATPase). It suppresses the upregulation of adhesion molecules in blood vessels, neutrophil activation, and the production of pro-inflammatory cytokines from activated endothelial cells. Furthermore, Lansoprazole induces the expression of various genes in gastric epithelial cells, including Phase II detoxifying enzymes (NADPH-quinone oxidoreductase, glutathione S-transferase) and antioxidative stress proteins (HO-1, thioredoxin reductase, and superoxide dismutase). In rat gastric epithelial cells, Lansoprazole upregulates HO-1 expression and exerts anti-inflammatory effects. |
| Alias | AG-1749, A-65006 |
| Molecular Weight | 369.36 |
| Formula | C16H14F3N3O2S |
| Cas No. | 103577-45-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | 1eq. HCl: 18.5 mg/mL (50 mM) DMSO: 50 mg/mL (135.37 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
1eq. HCl/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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