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(E/Z)-Polydatin

🥰Excellent
Catalog No. T2938Cas No. 65914-17-2
Alias Polydatin, (E/Z)-Piceid

(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.

(E/Z)-Polydatin

(E/Z)-Polydatin

🥰Excellent
Purity: 100%
Catalog No. T2938Alias Polydatin, (E/Z)-PiceidCas No. 65914-17-2
(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
Pack SizePriceAvailabilityQuantity
500 mg38 â‚¬In Stock
1 mL x 10 mM (in DMSO)42 â‚¬In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
In vitro
In a study involving mice with sepsis induced by cecal ligation and puncture, polydatin (15/45/100 mg/kg) was found to inhibit the production of serum TNF-α and IL-6, the protein expression of lung cyclooxygenase-2 and inducible NO synthase isoforms, and the activation of NF-κB, thereby reducing mortality and lung injury in a dose-dependent manner. The LD50 of polydatin in mice was determined to be 1 g/kg (i.p.).
In vivo
Polydatin is a PLA2 inhibitor that reduces the expression of sPLA2-IIA mRNA and the activity of phospholipase A2. It also increases the expression of Clara cell secretory proteins, thereby mitigating lipopolysaccharide-induced lung injury.
AliasPolydatin, (E/Z)-Piceid
Chemical Properties
Molecular Weight390.38
FormulaC20H22O8
Cas No.65914-17-2
SmilesOC[C@H]1O[C@@H](Oc2cc(O)cc(\C=C\c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.1.521 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (115.27 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5616 mL12.8080 mL25.6161 mL128.0803 mL
5 mM0.5123 mL2.5616 mL5.1232 mL25.6161 mL
10 mM0.2562 mL1.2808 mL2.5616 mL12.8080 mL
20 mM0.1281 mL0.6404 mL1.2808 mL6.4040 mL
50 mM0.0512 mL0.2562 mL0.5123 mL2.5616 mL
100 mM0.0256 mL0.1281 mL0.2562 mL1.2808 mL

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