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Terconazole

🥰Excellent
Catalog No. T2213Cas No. 67915-31-5
Alias Triaconazole, Terazol 7, Terazol 3, R42470, Gyno-Terazol

Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.

Terconazole

Terconazole

🥰Excellent
Purity: 99.94%
Catalog No. T2213Alias Triaconazole, Terazol 7, Terazol 3, R42470, Gyno-TerazolCas No. 67915-31-5
Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.
Pack SizePriceAvailabilityQuantity
25 mg$30In Stock
50 mg$43In Stock
100 mg$64In Stock
500 mg$153In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.
In vitro
Terconazole effectively inhibits the growth of Candida albicans ATCC 44859 in a concentration-dependent manner, demonstrating limited effects at 0.1 to 10 μM when cultured on media promoting the cell form. Its inhibitory impact on yeast cell viability varies across different Candida strains and species. Notably, C. albicans ATCC 44859's susceptibility to terconazole significantly increases on Eagle minimum essential medium, which encourages mycelium formation. The effects of terconazole range from inhibiting mycelia development at 0.1 μM to causing complete necrosis at 100 μM. Moreover, terconazole prevents the morphogenetic shift from the yeast to the filamentous form at concentrations between 0.008 and 0.05 microgram/mL.
In vivo
A three-day, once-daily, intravaginal administration of 0.8% terconazole typically ensures a functional therapeutic duration of seven days, owing to sustained, elevated levels of the biologically active antifungal in the vagina. Terconazole is well-tolerated, with no side effects reported at any concentration[2].
AliasTriaconazole, Terazol 7, Terazol 3, R42470, Gyno-Terazol
Chemical Properties
Molecular Weight532.46
FormulaC26H31Cl2N5O3
Cas No.67915-31-5
SmilesC([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)C)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=NC=N5
Relative Density.1.35g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (93.9 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8781 mL9.3904 mL18.7808 mL93.9038 mL
5 mM0.3756 mL1.8781 mL3.7562 mL18.7808 mL
10 mM0.1878 mL0.9390 mL1.8781 mL9.3904 mL
20 mM0.0939 mL0.4695 mL0.9390 mL4.6952 mL
50 mM0.0376 mL0.1878 mL0.3756 mL1.8781 mL

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