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NS-2028

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Purity:99.44%

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COA HNMR HPLC

NS-2028

Catalog No. T16344Cas No. 204326-43-2

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase (IC50: 17 nM and 20 nM). NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells (IC50: 30 nM). NS-2028 inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 decreases vascular endothelial growth factor-induced angiogenesis and permeability.

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Pack Size	Price	Availability
1 mg	$55	In Stock
5 mg	$133	In Stock
10 mg	$243	In Stock
25 mg	$438	In Stock
50 mg	$662	In Stock
100 mg	$953	In Stock
1 mL x 10 mM (in DMSO)	$148	In Stock

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Product Introduction

Bioactivity

Description	NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028 inhibits soluble Guanylyl Cyclase
In vitro	NS-2028 (10 μM; 30 mins) decreases VEGF-induced EC migration by inhibiting p38 MAPK activation. NS-2028 (10 μM; 24 hours) inhibits 25% cell number in comparation with those grown in the presence of a vehicle[2].
In vivo	In the avascular rabbit cornea, NS-2028 (p.o; 1 g/L; 8 days) displays an obvious reduction of new vessel formation in response to VEGF pellet implants[2].

Chemical Properties

Molecular Weight	269.05
Formula	C9H5BrN2O3
Cas No.	204326-43-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (929.20 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7168 mL	18.5839 mL	37.1678 mL	185.8391 mL
5 mM	0.7434 mL	3.7168 mL	7.4336 mL	37.1678 mL
10 mM	0.3717 mL	1.8584 mL	3.7168 mL	18.5839 mL
20 mM	0.1858 mL	0.9292 mL	1.8584 mL	9.2920 mL
50 mM	0.0743 mL	0.3717 mL	0.7434 mL	3.7168 mL
100 mM	0.0372 mL	0.1858 mL	0.3717 mL	1.8584 mL

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