Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryJapanJapan
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • 5-HT Receptor
    (1)
  • AAK1 (AP2 associated kinase 1)
    (1)
  • Apoptosis
    (4)
  • Autophagy
    (2)
  • Epigenetic Reader Domain
    (2)
  • Guanylate cyclase
    (11)
  • Histone Methyltransferase
    (5)
  • Parasite
    (2)
  • c-Met/HGFR
    (2)
  • Others
    (39)
Filter
Search Result
Results for "

sgc

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    66
    TargetMol | Activity
  • Dye Reagents
    2
    TargetMol | inventory
  • Natural Products
    10
    TargetMol | natural
SGC-CBP30
T66681613695-14-9
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
SGC-SMARCA-BRDVIII
T95681997319-84-2
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3), and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM, and 13 nM, respectively.
  • $39
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SGC-GAK-1
T51692226517-76-4
SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SGC-AAK1-1
T128852247894-32-0
SGC-AAK1-1, a potent and selective inhibitor of AAK1 (AP2-associated kinase 1), has an IC50 of 270 nM and a Ki of 9 nM, and serves as a chemical probe.
  • $64
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SGC-GAK-1N
T34631
SGC-GAK-1N is a negative control for SGC-GAK-1.
  • Inquiry Price
Size
QTY
SGC-iMLLT
T128862255338-25-9
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).
  • $46
5 days
Size
QTY
SGC-AAK1-1N
T346302242913-80-8
SGC-AAK1-1N is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1), with an IC50 of 1.8 μM [1].
  • $297
35 days
Size
QTY
SGC-UBD253
T79542
SGC-UBD253 is a potent antagonist of the HDAC6-UBD interaction and may be utilized in cancer research [1].
  • Inquiry Price
Size
QTY
SGC-CK2-1
T401312470424-39-4
SGC-CK2-1 is a highly specific inhibitor of CK2, a inducer of insulin production and secretion in pancreatic β-cells, and can be used in the study of neurodegenerative diseases.
  • $53
In Stock
Size
QTY
SGC agonist 1
T624711426309-31-0
SGC agonist 1 is a potent soluble guanylate cyclase (SGC) agonist that enhances solubility and exhibits high cell permeability.
  • $1,520
8-10 weeks
Size
QTY
SGC-STK17B-1
T695512650530-00-8
SGC-STK17B-1 is a potent and selective inhibitor of STK17B/DRAK2 kinase.
  • $1,520
6-8 weeks
Size
QTY
SGC 6870N
T37467
Negative control for SGC 6870 (Cat. No. 7182). SGC 6870N is the (S)-enantiomer, which is inactive on PRMT6.
  • $278
Backorder
Size
QTY
SGC 6870
T36976
Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM) Negative control SGC 6870N (Cat. No. 7184) also available.
  • $278
Backorder
Size
QTY
SGC agonist 2
T629092735713-77-4
SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist with potential therapeutic applications for cardiovascular diseases (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic diseases (renal fibrosis, systemic sclerosis).
  • $1,520
6-8 weeks
Size
QTY
SGC0946
T30821561178-17-3
SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.
  • $41
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
SGC707
T30841687736-54-4
SGC707 is a potent, selective, and cell-active allosteric inhibitor of [PRMT3].
  • $59
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SGC2085 HCl
T40131821908-49-9
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription a
  • $85
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SGC3027N
T34629
SGC3027N is a negative control for SGC3027 (GLXC-12451).
  • Inquiry Price
Size
QTY
SGC6870
T695802561471-27-8
SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.
  • $548
35 days
Size
QTY
SGC2085
T70891821908-48-8
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).
  • $80
In Stock
Size
QTY
Nelociguat
T7201625115-52-8
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Quinacrine dihydrochloride
T094269-05-6
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
  • $41
In Stock
Size
QTY
TargetMol | Citations Cited
H1k
T72057 In house
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1.
  • $195
In Stock
Size
QTY
BAY-678
T10473675103-36-3In house
BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).
  • $35
In Stock
Size
QTY
SGC3027
T12887
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.
  • Inquiry Price
Size
QTY
Cinaciguat
T1984329773-35-5
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure.
  • $66
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Lificiguat
T4381170632-47-0
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
  • $43
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Poncirin
T3S231214941-08-3
1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enhances osteoblast differentiation in mesenchymal stem cellsincreased bone mineral density, and improves trabecular microarchitecture likely reflect increases bone formation and decreases bone resorption in GIO mice.
  • $80
In Stock
Size
QTY
TargetMol | Citations Cited
β,β-Dimethylacrylshikonin
T3S234424502-79-2
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
  • $130
In Stock
Size
QTY
TargetMol | Inhibitor Sale
(Rac)-MGV354
T126701852495-86-3
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively).
  • $70
In Stock
Size
QTY
TargetMol | Inhibitor Sale
BAY 41-8543
T21712256498-66-5
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
  • $40
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ODQ
T1977741443-28-1
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
  • $42
In Stock
Size
QTY
TargetMol | Inhibitor Sale
2-Desoxy-4-epi-pulchellin
TN2755122872-03-1
2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows significant antiviral (H1N1 and H3N2) activities, it also displays significant antimycobacterial activity (IC50=7.6 uM).
  • $122
In Stock
Size
QTY
TargetMol | Inhibitor Sale
BAY-474
T79001033767-86-0
BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe
  • $76
In Stock
Size
QTY
TargetMol | Inhibitor Sale
NS-2028
T16344204326-43-2
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM), inhibits 3-morpholino-sydnonimine (SIN-1)-elicited cyclic GMP formation in human cultured umbilical vein endothelial cells (IC50: 30 nM), and completely inhibits NO-dependent relaxant responses in non-vascular smooth muscle (1 μM). NS-2028 also decreases vascular endothelial growth factor-induced angiogenesis and permeability.
  • $55
In Stock
Size
QTY
TargetMol | Inhibitor Sale
BAY 41-2272
T6775256376-24-6
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
THPP-1
T85061257051-63-0
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Sale
c-Met-IN-19
T79715
c-Met-IN-19 (Compound 21j) is a potent c-Met inhibitor with an IC50 of 1.99 nM, demonstrating cytotoxic effects on various cancer cell lines, including A549, HT-29, SGC-7901, and MDA-MB-231, with IC50 values of 0.25, 0.36, 0.98, and 0.76 μM, respectively [1].
  • Inquiry Price
Size
QTY
BI 703704
T105362740807-77-4
BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].
  • $1,520
10-14 weeks
Size
QTY
BAY-747
T751371609342-18-8
BAY-747 (BAY 1165747) is an orally administered, brain-penetrant compound that stimulates soluble guanylate cyclase (sGC). It effectively counteracts memory impairments induced by L-NAME, improves cognitive performance in rats during the object location task (OLT), reduces blood pressure in conscious normotensive and spontaneously hypertensive rats (SHR), and enhances skeletal muscle function in the mdx mTRG2 mouse model of Duchenne muscular dystrophy (DMD) [1] [2] [3].
  • Inquiry Price
Size
QTY
Praliciguat
T165691628730-49-3
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
  • $153
In Stock
Size
QTY
Ivangustin
TN434014164-59-1
Ivangustin, a sesquiterpene lactone derived from the medicinal plant Inula britannica, exhibits significant cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines.
  • $193
In Stock
Size
QTY
Methylene blue hydrate
T75339122965-43-9
Methylene Blue (Basic Blue 9) hydrate functions as an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). This compound, known for its vasopressor activity, is widely utilized as a dye in various medical procedures. It operates via the nitric oxide synthase/guanylate cyclase signaling pathway to diminish prepulse inhibition and possesses the capacity to cross the blood-brain barrier. Methylene Blue hydrate acts as a REDOX cycling compound and inhibits Tau protein aggregation. Moreover, it is effective in reducing cerebral edema, damping microglial activation, and alleviating neuroinflammation, demonstrating its multifaceted therapeutic potential [1] [2] [3].
    Inquiry
    IWP-051
    T322421354041-91-0
    IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of pote
    • $2,120
    8-10 weeks
    Size
    QTY
    NVS-CECR2-1
    T371511992047-61-6
    NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 μM by Alpha screen, Kd = 0.80 μM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has no acute toxicity. See the Structural Genomics Consortium (SGC) website for more information.
    • $108
    In Stock
    Size
    QTY
    Cytoglobosin C
    T754511221163-94-5
    Cytoglobosin C, a derivative of cytochalasan, demonstrates significant cytotoxic effects on SGC-7901 and A549 cell lines, with an inhibitory concentration (IC50) of less than 10 μM [1].
    • Inquiry Price
    Size
    QTY
    MY-1076
    T777293008262-76-5
    MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibited the proliferation of MGC-803, SGC-7901, HCT-116, and KYSE450 cells.
    • $30
    In Stock
    Size
    QTY
    Tubulin polymerization-IN-30
    T620402521560-46-1
    Tubulin polymerization-IN-30 (compound 6e) is a potent inhibitor of tubulin polymerization that disrupts intracellular microtubule organization and arrests the cell cycle at the G2 M phase. Tubulin polymerization-IN-30 exhibits high potency against cancer cell lines HeLa, SGC-7901, and A549, with IC 50 values of 0.403, 2.16, and 2.21 μM, respectively.
    • $1,520
    6-8 weeks
    Size
    QTY
    GSK 591 dihydrochloride
    T369812320953-89-5
    Potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro. To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.
    • $928
    35 days
    Size
    QTY
    (Rac)-BI 703704
    T126611423067-48-4
    (Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC).
    • $2,570
    10-14 weeks
    Size
    QTY