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Praliciguat

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Purity:99.05%

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COA HNMR HPLC

Praliciguat

Catalog No. T16569Cas No. 1628730-49-3

Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.

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Pack Size	Price	Availability
1 mg	$153	In Stock
2 mg	$229	In Stock
5 mg	$387	In Stock
10 mg	$597	In Stock
25 mg	$953	In Stock
50 mg	$1,290	In Stock
100 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$455	In Stock

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Product Introduction

Bioactivity

Description	Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
Alias	IW-1973

Chemical Properties

Molecular Weight	534.36
Formula	C21H14F8N6O2
Cas No.	1628730-49-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 245 mg/mL (458.50 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8714 mL	9.3570 mL	18.7140 mL	93.5699 mL
5 mM	0.3743 mL	1.8714 mL	3.7428 mL	18.7140 mL
10 mM	0.1871 mL	0.9357 mL	1.8714 mL	9.3570 mL
20 mM	0.0936 mL	0.4678 mL	0.9357 mL	4.6785 mL
50 mM	0.0374 mL	0.1871 mL	0.3743 mL	1.8714 mL
100 mM	0.0187 mL	0.0936 mL	0.1871 mL	0.9357 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc