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GSK 591 dihydrochloride

Catalog No. T36981Cas No. 2320953-89-5

Potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro. To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.

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Pack Size	Price	Availability	Quantity
10 mg	$928	35 days

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	453.41
Formula	C22H30Cl2N4O2
Cas No.	2320953-89-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 45.34 mg/mL(100 mM)

DMSO: 45.34 mg/mL(100 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.2055 mL	11.0275 mL	22.0551 mL	110.2755 mL
5 mM	0.4411 mL	2.2055 mL	4.4110 mL	22.0551 mL
10 mM	0.2206 mL	1.1028 mL	2.2055 mL	11.0275 mL
20 mM	0.1103 mL	0.5514 mL	1.1028 mL	5.5138 mL
50 mM	0.0441 mL	0.2206 mL	0.4411 mL	2.2055 mL
100 mM	0.0221 mL	0.1103 mL	0.2206 mL	1.1028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc