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SGC3027

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SGC3027

Catalog No. T12887

SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.

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100 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.
In vitro	SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases.SGC3027 inhibits the methylation of HSP70(IC50=1.3 μM, in cellular assays using C2C12 cells)[2].

Chemical Properties

Molecular Weight	787.37
Formula	C41H47ClN6O6S
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (317.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2701 mL	6.3503 mL	12.7005 mL	63.5025 mL
5 mM	0.2540 mL	1.2701 mL	2.5401 mL	12.7005 mL
10 mM	0.1270 mL	0.6350 mL	1.2701 mL	6.3503 mL
20 mM	0.0635 mL	0.3175 mL	0.6350 mL	3.1751 mL
50 mM	0.0254 mL	0.1270 mL	0.2540 mL	1.2701 mL
100 mM	0.0127 mL	0.0635 mL	0.1270 mL	0.6350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SGC3027SGC-3027SGC 3027