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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,715 | 10-14 weeks | |
50 mg | $2,885 | 10-14 weeks |
Description | MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2]. |
In vitro | Treatment with MGV354, ranging from 0.1 nM to 10 μM, for one hour induces a dose-dependent elevation in cGMP levels within normal human trabecular meshwork (NTM) cells, showcasing an average effective concentration (EC50) of 2.5±1.6 nM after ODQ (20 μM) administration. The resultant average cGMP concentration achieved by MGV354 in NTM cells is 46±28 nM. Moreover, at a concentration of 1 μM, MGV354 consistently augments intracellular cGMP levels in NTM cells in a linear, time-dependent fashion, under assay conditions extending up to three hours [3]. |
In vivo | MGV354 (Compound (+)-23) robustly lowers intraocular pressure in a cynomolgus model of elevated intraocular pressure over 24 h after a single topical ocular drop and has been selected for clinical evaluation [1]. |
Molecular Weight | 575.7 |
Formula | C35H37N5O3 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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