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BI 703704

Catalog No. T10536Cas No. 2740807-77-4

BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].

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Pack Size	Price	Availability
25 mg	$1,520	10-14 weeks
50 mg	$1,980	10-14 weeks
100 mg	$2,500	10-14 weeks

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Product Introduction

Bioactivity

Description

BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].

In vivo

BI 703704 administered at dosages of 0.3 to 10 mg/kg through food intake daily for 15 weeks in fifty-eight male ZSF1 rats aged 12-13 weeks led to a dose-dependent reduction in urinary protein excretion (UPE) and a dose-dependent elevation in renal cGMP levels [1]. The compound effectively increases renal cGMP in a dose-responsive manner, thereby decelerating the progression of diabetic nephropathy under conditions of oxidative stress [1].

Chemical Properties

Molecular Weight	559.72
Formula	C32H37N3O4S
Cas No.	2740807-77-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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Keywords

BI 703704BI-703704BI703704