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H1k
🥰Excellent
Catalog No. T72057
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1.
H1k
🥰Excellent
Purity: 98.38%
Catalog No. T72057
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,970 | In Stock |
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Purity:98.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1. |
| Targets&IC50 | LS-180:2.9 μM, A549 cells:14.8 μM, HepG2 cells:9.6 μM, MDA-MB-231 cells:20.5 μM, SGC-7901:12.1 μM |
| In vitro | H1k (72 h) exhibits anti-proliferative activity against LS-180, HepG-2, SGC-7901, A549, and MDA-MB-231 cells, with IC50 values of 2.9, 9.6, 12.1, 14.8, and 20.5 μM respectively [1].H1k (0-50 μM; 24 h) triggers significant G2-M arrest in MDA-MB-231 and SGC-7901 cells in a dose-dependent manner [1]. H1k (0-20 μM; 6 h; MDA-MB-231 cells) induces autophagy to exert its anti-proliferative activity, with lysosomes being its functional target [1]. |
| Molecular Weight | 390.48 |
| Formula | C27H22N2O |
| Smiles | C=C(C1=CC=CC=C1)C2=NC=CC3=C2N(CC4=CC=C(OC)C=C4)C5=CC=CC=C53 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.9 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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