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THPP-1

Catalog No. T8506Cas No. 1257051-63-0

THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).

THPP-1

THPP-1

Purity: 99.46%
Catalog No. T8506Cas No. 1257051-63-0
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$73In Stock
25 mg$158In Stock
50 mg$268In Stock
100 mg$395In Stock
200 mg$563In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Purity:99.46%
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Product Introduction

Bioactivity
Description
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
Targets&IC50
PDE10A:1-1.3 nM
In vivo
Consistent with rodent data, both THPP-1 and risperidone significantly attenuated the stimulant effects in SIMA when administered alone, though some differences were noted.?Combination therapy with a low dose of risperidone produced significantly more robust effects.?THPP-1 and risperidone also produced a marked reduction of wake cycle time and gamma frequency power in EEG.?However, THPP-1 differed from risperidone by reducing spectral power of lower frequencies[1].
Chemical Properties
Molecular Weight464.9
FormulaC23H21ClN6O3
Cas No.1257051-63-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 31 mg/mL (66.68 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1510 mL10.7550 mL21.5100 mL107.5500 mL
5 mM0.4302 mL2.1510 mL4.3020 mL21.5100 mL
10 mM0.2151 mL1.0755 mL2.1510 mL10.7550 mL
20 mM0.1076 mL0.5378 mL1.0755 mL5.3775 mL
50 mM0.0430 mL0.2151 mL0.4302 mL2.1510 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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